Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotor: S.J. Edixhoven

Promotor: Prof.dr. J.P. Abrahams

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

An algorithm is discussed to compute the exponential representation of principal units in a finite extension field F of the p-adic rationals.

This thesis introduces the concept of

Levende Talen en het Expertisecentrum mvt hebben in 2009 de Gerard Westhoff-Taaldidactiekprijs ingesteld voor de beste scriptie op het gebied van vreemdetalendidactiek (in brede zin, inclusief de didactiek van literatuur en cultuur), geschreven door studenten aan Nederlandse lerarenopleidingen. Voor…

Gevolgen voor de klas en tips voor de leerkracht

Firearms and violence in Europe–A systematic review by Katharina Krüsselmann, Pauline Aarten, Marieke Liem

De onderzoeksteams zijn opgezet, samenwerkingen zijn gestart, projecten afgetrapt, de eerste startsubsidies zijn binnen en de websites zijn in de lucht. Het stimuleringsprogramma Citizenship, Migration and Global Transformations, dat bestaat uit de twee pijlers Social Citizenship and Migration en Global…

Nu zowel oude als nieuwe democratieën steeds vaker te maken krijgen met negative ontwikkelingen op democratisch gebied, is er vanuit maatschappelijk oogpunt behoefte om het ontwerp en de effectiviteit van democratische 'checks and balances' te herzien. Het doel van de conferentie op vrijdag 9 juni is…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The key purpose of this project is to study tautological relations on the level of closed differential forms or even integral cochains (i.e. we don't take classes in cohomology).

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Promotor: T.J. Aartsma, Co-promotor: R.N. Frese

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotor: F.J. van Lunteren, E. Jorin

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

Astronoom Jos de Boer heeft in Nice de Chesneauprijs in ontvangst genomen voor zijn onderzoek naar zogeheten protoplanetaire schijven. De prijs wordt toegekend aan het beste sterrenkundige proefschrift op het gebied van hoge ruimtelijke resolutie. ‘Ik zie het als een goede kans om over mijn onderzoek…

Een internationaal team van astronomen van onder andere de Leidse Sterrewacht, heeft voor het eerst een stukje van het donkere, kosmisch web in kaart gebracht. Het onderzoek versterkt de hypothese dat het jonge heelal bestond uit enorme aantallen, kleine groepjes pasgevormde sterren. De astronomen publiceren…

Wiskunde en Natuurwetenschappen

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Van 11 tot 17 september staat Leiden in het teken van kunst en wetenschap. Wat kan de combinatie van deze twee velden voor ons betekenen? En hoe kan de samenwerking ertussen worden versterkt? Verschillende publieksevents en een spiksplinternieuw symposium voor specialisten moeten antwoord geven op deze…

Geesteswetenschappen, Centre for Linguistics

Governance and Global Affairs, Institute of Security and Global Affairs