Cardiovascular diseases are still a major concern for the global health.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

De focus van dit proefschrift is het leren en de samenwerking van docenten in het voortgezet onderwijs.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Fundamental research in the ALgebra, Geometry And Number Theory

Promotor: M. Ubbink, Co-promotor: G. Siegal

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Curved single crystals provide variable, but well-defined surface structures.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotores:Th.J.C. van Berkel, M. van Eck

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

The cases of building materials, automobility, mushrooms and plastics.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis is about cosmological inflation and its relation to observations.

Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Promotor: Prof.dr. J.N. Kok

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.