Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

We consider the propagation of electrical signals through nerve fibres.

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Promotor: B.van de Water, Co-promotor: L.S.Price

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Promotie

Promotie

Veel handgeschreven en geïllustreerde archieven bevatten een schat aan informatie, maar worden weinig bestudeerd vanwege hun complexe en door computers moeilijk te ontcijferen inhoud. Het doel van dit project is een digitale omgeving te ontwikkelen die hier een oplossing voor biedt, en die de heterogene…

De Sterrewacht biedt volledige opleidingsprogramma's aan waarbij onderzoek en onderwijs met elkaar zijn verweven. Lees alles over de bacheloropleiding Sterrenkunde en de masteropleiding Astronomy in Leiden.

De Ada Lovelace Distinguished Lecture Series brengt excellente computerwetenschappers van over de hele wereld naar de Universiteit Leiden. De sprekers delen spannende ideeën en resultaten uit de voorhoede van de wetenschap.

Antibiotica Gezocht! is een initiatief van medewerkers en studenten van de Universiteit Leiden en het Erasmus Medisch Centrum in Rotterdam. Zij doen onderzoek naar antibiotica en de bacteriën die antibiotica produceren. In 2011 wonnen wij de Academische Jaarprijs met het project Antibiotica Gezocht!…

Bouwprojecten Vastgoed Universiteit Leiden

Op 19 februari 2020 verdedigde Richard Jiang zijn proefschrift '‘Greening’ the WTO Ban on China’s Export Duties'. Het promotieonderzoek is begeleid door promotor prof.dr. M.C.E.J. Bronckers.

Een onderzoek naar voor wie, wanneer en waarom de Cool Little Kids interventie werkt.

Hoewel prominente juridisch-filosofische debatten worden erkend, stelt dit project een radicaal andere benadering voor om inzicht te verschaffen in het concept van de rechtsstaat.

Hoe dragen verschillende levensloopfactoren bij aan financiële kwetsbaarheid onder gepensioneerden in Nederland, en hoe kunnen gerichte interventies en beleidsmaatregelen de financiële weerbaarheid van deze groepen vergroten?

Trouw bespreekt het boek ‘Zo doen vogels dat’, waarin wetenschapsjournaliste Jennifer Ackerman aan de hand van diverse gedragsonderzoeken laat zien dat vogels intelligenter zijn dan algemeen wordt aangenomen. Emeritus hoogleraar Gedragsbiologie Carel ten Cate deed jarenlang onderzoek naar grammatica…

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Promotor: Prof.dr. H.S. Overkleeft

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Machine Learning is becoming a more and more substantial technology for industry.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.