This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

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Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: Prof.dr. T.H.W. Bäck

Promotores: J.C. van Houwelingen, S.A. van de Geer

Promotor: Prof.dr. M. Danhof

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: Prof.dr. A.W. van der Vaart

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Peter Stevenhagen

Promotor: A.W. van der Vaart

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Emeritus hoogleraar Adoptiestudies Femmie Juffer heeft haar onderzoeksrapport 'Beslissingen over kinderen in problematische opvoedingssituaties - Inzichten uit gehechtheidsonderzoek' uit 2010 op verzoek van de Expertgroep Jeugdrechters bijgewerkt met recente wetenschappelijke kennis over gehechtheid.…

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Promotor: M.A.G.J. Orrit

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Promotor: F. Arbab

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Hieronder informatie over deze adviesraad.

In het schoolvak scheikunde is de concept-context benadering ingevoerd. Hans Vogelzang onderzocht of de Scrum-methodologie kan helpen bij het vormgeven van lessen met deze benadering.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotores: H.A. Udo De Haes, P.M. Brakefield

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Wij onderzoeken talen in hun historische context, met als doel de aard van de taalvariatie in het verleden te begrijpen en te verklaren in hoeverre de socioculturele context van vroeger heeft bijgedragen aan het vormen van de taalvariatie en taalverandering.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The focus of the dissertation

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.