Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Artful Mathematics: The Heritage of M. C. Escher

Benieuwd of de bachelor opleiding English Language and Culture aan Universiteit Leiden bij je past? We vertellen je alles over de opleiding.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Maar liefst veertien sprekers lieten op 8 juni in Plexus hun licht schijnen over de integratie van statushouders op lokaal niveau. Het leverde een waaier van verhalen op.

De aanmelding van migranten en asielzoekers in Ter Apel is overbelast. Dat beeld is prominent in de media. In podcast De Verbranders gaan promovendi Neske Baerwaldt en Wiebe Ruijtenberg in gesprek om thema’s als migratie, grenzen en de vluchtende mens vanuit verschillende kanten te belichten.

GTGC blikt terug op een andere succesvolle editie van haar jaarlijkse conferentie. Van 5 tot en met 7 juni hield het programma haar derde internationale conferentie, dit jaar met als thema 'Emerging Trends in Global Governance'.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

De stormachtige ontwikkelingen in China van de laatste jaren hebben geleid tot een grote belangstelling voor China. Er is vrijwel geen land, regio, sector of specialisatie waar China niet een rol in speelt.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Sheltering is an immediate human need and determines well-being andhealth.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Promotor: Prof.dr. J. den Hertog

Cardiovascular diseases are still a major concern for the global health.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Sustainable energy from wind and solar is most readily available near the sea.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Consequences for sediment stability and seston trapping

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Benieuwd naar hoe de Universiteit en de bijbehorende faculteit in elkaar steekt? Lees daar meer over op deze pagina.

Op 1 februari 2018 verdedigde Nathalie-Sharon Koster haar proefschrift getiteld ‘Crime victims and the police’. Het promotieonderzoek is begeleid door promotoren prof. dr. J.P. van der Leun en dr. mr. M.J.J. Kunst.

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotor: Prof.dr. C.U. Keller

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Promotor: M.A.G.J. Orrit

Het kabinet is gevallen over de asielinstroom. Volgens Mark Rutte zou die ‘twee of drie keer hoger zijn dan normaal’. In radioprogramma ‘OVT’ gaat hoogleraar Marlou Schrover in op onder meer deze uitspraak.