921 zoekresultaten voor “were en regelgeving” in de Publieke website
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Onderzoek
Het onderzoek van de afdeling Economie is ondergebracht bij meerdere facultaire programma's. Het onderzoek van de afdeling richt zich thans met name op sociaal-economische vraagstukken, rechtseconomie en fiscale economie.
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Conferentie 'Leadership in Progress: Science meets Practice' - Een Terugblik
Op 15 oktober 2020 verzamelden internationale wetenschappers, vertegenwoordigers uit de praktijk en studenten zich online bij het Leiden Leadership Centre voor de conferentie ‘Leadership in Progress: Science meets practice’. Samen met gerenommeerde sprekers uit de wetenschap, politiek en de ambtelijke…
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Towards artificial photosynthesis on the lipid bilayer of liposomes
Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Shaping the European External Action Service and its post-Lisbon crisis management structures
This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Learning from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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The Proliferation of Dissenting Opinions in International Law
Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Ecology of the Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Compressed Σ-Protocol Theory
In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Forgotten Lineages. Afterlives of Dutch Slavery in the Indian Ocean World
Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Maartje van der Woude ontvangt Heineken Young Scientist Award
Hoogleraar Rechtssociologie Maartje van der Woude (37) is een van de vier jonge wetenschappers die door de KNAW met een Heineken Young Scientists Award 2018 wordt bekroond. Van der Woude krijgt de award in het domein Humanities voor haar onderzoek naar de wisselwerking tussen het recht en het publieke…
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Fiscalisten staan onder vuur: 'Ik word aangezien voor schimmig'
Fiscalisten staan onder vuur in de publieke opinie. Ze worden direct verantwoordelijk gehouden voor de belastingontwijking door multinationals. Universitair docent Elody Hutten doet onderzoek naar hoe belastingprofessionals omgaan met deze kritiek en werd hierover geïnterviewd door het Financieele D…
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Meuwese over de actualiteit van de kabinetsreactie op de kinderopvangtoeslagaffaire
De laatste dagen en weken buitelden de experts over elkaar heen om de hoofdschuldige in de kinderopvangtoeslagaffaire aan te wijzen. Die discussie is boeiend, maar even belangrijk zijn de bredere lessen die we voor het staats- en bestuursrecht uit de affaire kunnen trekken, aldus Anne Meuwese, hoogleraar…
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'De jurist van vandaag ontkomt niet aan AI'
Artificiële intelligentie (AI) is overal en zal nooit meer verdwijnen. Steeds meer facetten van het dagelijks leven, van de wijze waarop wij nieuws tot ons nemen tot onze interacties met bedrijven en overheden, worden beïnvloed door een vorm van AI.
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Code voor kinderrechten: ontwerpen in het belang van het kind
Op vrijdag 12 maart 2021 is de website code voor kinderrechten (www.codevoorkinderrechten.nl) gelanceerd. Deze code helpt ontwikkelaars en ontwerpers van digitale diensten om deze te ontwikkelen in het belang van het kind.
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Tanja Masson-Zwaan: nog altijd geen plicht om ruimtepuin op te ruimen
Ruimtevaart gaat allang niet meer alleen over raketten, reizen naar de maan en Rusland en Amerika. Nederland heeft een eigen ruimtevaartorganisatie, waar verzameling en verstrekking van steeds geavanceerdere satellietdata een belangrijke taak is.
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Presentatie masterscriptie tijdens conferentie Reshaping Work
Francine van Vlijmen, net afgestudeerd in Staats- en Bestuursrecht aan de Universiteit Leiden, heeft op 20 oktober een poster-presentatie gegeven tijdens de conferentie “Reshaping Work in the Sharing Economy” in Amsterdam.
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EBM-student Danique Reidsma presenteert onderzoek tijdens symposium NGSZ
Danique Reidsma, student Economie, Bestuur en Management (EBM) aan de Universiteit Leiden, heeft onlangs een presentatie gegeven tijdens een symposium van het Nederlands Genootschap Sociale Zekerheid (NGSZ) in Den Haag. Haar presentatie ging over de vraag of eHealth kan helpen om de zorgkosten beheersbaar…