Promotor: J.N. Kok, Co-promotor: M.S. Lew

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

In this work, we attempt to answer the question:

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: S.M. Verduyn Lunel

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Promotor: Prof.dr. M. Ubbink

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: T. Schmidt

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: P.D. Grünwald

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: Prof.dr. M.L. van Hecke

Promotor: J.W.M. Frenken