Promotie

Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

The ultimate aim of this project is to improve cooperation between courts in different Member States.

Publicaties Opleiden, trainen, oefenen en leren in crisisbeheersing en rampenbestrijding

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Promotie

Promotie

Lezing

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. J.W.M. Frenken

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotores: W. Jiskoot, F. Ossendorp

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

De LUMC Alumni Vereniging is in 1996 opgericht om enerzijds de band tussen het Leids Universitair Medisch Centrum en zijn alumni te versterken, anderzijds om de band van de alumni onderling te versterken.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Dit programma heeft tot doel de gedigitaliseerde archiefbronnen van de archieven van Kerala en Tamil Nadu toegankelijker te maken voor Indiase en internationale wetenschappers en voor een zo breed mogelijk publiek, in het bijzonder voor de bevolking van Kerala.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Door haar activiteiten, draagt het Europa Instituut bij aan het begrip en de ontwikkeling van de snel evoluerende integratie in Europa.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

Overzicht van de vacatures bij de afdeling Economie.

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

Promotor: Prof.dr. J.P. Abrahams

Universiteit Leiden realiseert een nieuw en duurzaam gebouw met state of the art onderzoek –en onderwijsfaciliteiten voor de Faculteit der Wiskunde en Natuurwetenschappen, het Gorlaeus Gebouw. Het ontwerp van dit gebouw, middenin het hart van de Science Campus en het Leiden Bio Science Park, stimuleert…

Promotor: Prof.dr. M. Ubbink

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.