Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Afrika heeft een bevolking van 1,5 miljard mensen. In 2050 zal dit aantal naar verwachting stijgen tot 2,5 miljard. De impact van het continent op de wereldeconomie en samenlevingen, maar ook op het milieu, zal daardoor enorm toenemen.

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

In Afrika wonen 1,5 miljard mensen. Over 30 jaar zijn dat er 2,5 miljard. De impact van het continent op de wereldeconomie, maar bijvoorbeeld ook op het milieu, zal daardoor enorm toenemen. Onderzoekers van het Afrika-Studiecentrum Leiden (ASCL) zijn zich er al decennia van bewust dat Afrika een cruciale…

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

Op de Oude Sterrewacht bieden we een aantal manieren voor scholen om op bezoek te komen. Naast de rondleidingen die wij organiseren zijn er speciaal voor scholen ook workshops te doen.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Do selenium nanoparticles in fish food cause subtle alterations in behavior of fish: effect of particles size and concentration?

Duurzaamheid is een van de centrale aandachtspunten van de Universiteit Leiden en speelt een steeds grotere rol binnen het onderwijs en onderzoek van de Faculteit der Rechtsgeleerdheid. Binnen deze context levert de afdeling Sociaal Recht een belangrijke bijdrage aan het debat en onderzoek rondom Business…

Duurzaamheid is een van de centrale aandachtspunten van de Universiteit Leiden en speelt een steeds grotere rol binnen het onderwijs en onderzoek van de Faculteit der Rechtsgeleerdheid. Binnen deze context levert de afdeling Sociaal Recht een belangrijke bijdrage aan het debat en onderzoek rondom Business…

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Promotor: Prof.dr. A. Achucarro

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Hoe en in welke mate kunnen groepen clinici en biomedici kennis uit klinische vakken en kennis uit de basisvakken expliciet maken en aan elkaar relateren?

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: E.F. Smets, Co-promotor: J. Geml

This thesis describes the design, characterization and application of dextran based crosslinked network.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Dit artikel geschreven door Marieke Liem & Alexander Kamprad onderzoekt de relatie tussen terrorisme en interpersoonlijk geweld. Ze voerden cross-nationale analyses uit over de effecten van mortaliteitscijfers voor het terrorisme op moordcijfers. Uit de resultaten bleek dat terrorisme sterk en positief…

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.