In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: Prof.dr. M. Danhof

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Schulden en de bijbehorende stress zijn een groeiend probleem onder jongeren. Alleen: veel jongeren schamen zich voor hun geldproblemen, waardoor ze te laat aan de bel trekken. Daarom schoof de Leidse hoogleraar Wilco van Dijk in debatcentrum De Balie aan bij de minister Schouten van Armoedebeleid en…

Op 15 februari vertellen oud-studenten Methodologie & Statistiek (M&S) over hun beroep om huidige M&S-studenten inzicht te geven in hun loopbaanperspectieven.

Hoogleraar Mariska Kret ontvangt de Mercator Sapiens Stimulus, een nieuwe wetenschapsprijs van de Koninklijke Hollandsche Maatschappij (KHMW). Aan de prijs is een geldbedrag van 1 miljoen euro verbonden.

Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

De masterspecialisatie Sociology of Policy in Practice biedt de mogelijkheid om een onderzoeksstage te doen om het beleid van een bedrijf of organisatie in de praktijk te bestuderen..

Wij zijn gevestigd in het Pieter de la Courtgebouw van de Faculteit der Sociale Wetenschappen van de Universiteit Leiden.

In de masterspecialisatie Visual Ethnography leer je de kneepjes van het vak om etnografisch onderzoek met audiovisuele methodes te doen.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

De kans om een nieuw, spannend onderwerp te onderzoeken. Dat is hoe Lennart Schada von Borzyskowski zijn succesvolle beursaanvraag voor de NWO XS-beurs noemt. Deze 50.000 euro zal de onderzoeker van het Instituut Biologie Leiden (IBL) spenderen aan het ontwikkelen van een nieuwe methode om op duurzame…

Lezing, Lezing onderdeel van serie

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

Festival, Diploma-uitreiking

Hoe kan ‘Big Data’ worden ingezet bij ontwikkelings- en humanitaire hulp en wat zijn de risico’s daarvan? De Universiteit Leiden en United Nation’s Global Pulse organiseren hierover op 23 oktober in Den Haag een internationale expert meeting.

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Festival, Diploma-uitreiking

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