The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Including modelling as part of software development appears to have various benefits.

Promotie

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

De Leidse masterstudent Arend Moerman heeft een tien gekregen voor zijn afstudeeronderzoek naar de simulatie van de chaotische interacties van drie zwarte gaten. Uit de simulaties blijkt dat lichtere zwarte gaten elkaar meestal wegslingeren, terwijl zwaardere vooral samensmelten. Het onderzoek, een…

Met haar project WetSuite wil Meuwese AI-technieken die gebruikt kunnen worden om juridische overheidsdocumenten te analyseren toegankelijk maken voor een brede groep onderzoekers.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Op 20 juni verdedigde Anne Hendrikx het proefschrift 'Methoden van contractsuitleg: een model voor de uitleg van een overeenkomst'. Het promotieonderzoek is begeleid door Henk Snijders.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotor: K.J. Batenburg

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

De nieuwste Europese quantumcomputer komt in Nederland. De ict-coöperatie van Nederlandse onderwijs- en onderzoeksinstellingen SURF krijgt hiervoor financiering van het Europese EuroHPC-programma. Leidse onderzoekers hebben een belangrijke rol: zij ontwerpen de algoritmes en de machine learning routes,…

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Shabaz Sultan en Simon Portegies Zwart, met de hulp van Vincent Icke, hebben één van de tien Surf Innovation Challenge Awards gewonnen voor hun onderzoek naar 'Interactive high-performance laboratory for Chaos'. De winnaars hebben een geldprijs van 10.000 euro ontvangen en krijgen 6 maanden (tot 1 juni…

Mosselen in mosselbedden vormen een patroon dat lijkt op de organisatie van moleculen en atomen in materialen als brons, staal of rubber. Dit gedrag kan dan ook worden beschreven met hetzelfde wiskundige model.

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Het verzamelen en interpreteren van grote hoeveelheden data is niet meer weg te denken uit de maatschappij en de wetenschap. De Universiteit Leiden is een kennis- en expertisecentrum van data science dat de nadruk legt op interdisciplinaire samenwerking en innovatie.

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.