Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Planeten in andere zonnestelsels bevatten waardevolle informatie over het ontstaan van planeten en leven. Promovenda Yapeng Zhang heeft hun atmosferen bestudeerd door te kijken naar hun kleinste onderdelen: isotopen. Met haar onderzoek hoopt ze te ontdekken wat ons eigen zonnestelsel uniek maakt.

Tijdens het bestuderen van zestien jaar aan meetgegevens van jonge sterren ontdekte de Leidse masterstudent Sam de Regt dat twee van die sterren nog gehuld waren in geboortewolken. Nog niet eerder bracht iemand deze twee sterren zo scherp in beeld. Hij publiceert zijn opschoonmethode en de nieuwe afbeeldingen…

Sociale Wetenschappen, Psychologie

Promotor: W.Th.F. den Hollander

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Wat doet de Universiteit Leiden om haar gebouwen en campussen toekomstbestendig en onafhankelijk van fossiele energie te maken?

Research

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

KNIR cursus voor BA and MA studenten - Deadline voor inschrijving: 15 January 2017

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

How can we develop and further improve life cycle impact assessment methods, characterisation factors and normalisation factors?

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: R. Gill, Co-promotor: P. Massart

HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.

Promotores: Wim Jiskoot; Ferry Ossendorp

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotor: C.J. ten Cate

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: J.W.M. Frenken

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)