1,174 zoekresultaten voor “specific for a” in de Publieke website
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Hunting for the fastest stars in the Milky Way
The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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The hunt for frozen organic molecules in space
Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.
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Intermittency and Number Expansions for Random Interval Maps
This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.
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Inverse problems for universal deformation rings of group representations
Promotor: Prof.dr. P. Stevenhagen
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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Network analysis methods for smart inspection in the transport domain
Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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Highly Accurate Simulations and Benchmarking of Molecule-Surface Reactions
Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.
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RiskCycle: Risk-based management of chemicals and products in a circular economy at a global scale
How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?
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Reducing daily-stress: Breaking a habit
Stress komt veel voor in de huidige samenleving. Dit is zorgwekkend, aangezien onderzoek herhaaldelijk heeft aangetoond dat stress een negatieve invloed heeft op de lichamelijke gezondheid. Zo vergroot stress bijvoorbeeld de kans op hart- en vaatziekten.
- Elastin-like polypeptide micelles for vaccine delivery
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the Utilisation of the Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete, Greece
Promotor: Prof.dr. L.J. Slikkerveer
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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Diagnostics for mechanical heating in star-forming galaxies
Promotor: F.P. Israel, Co-Promoter: R. Meijerink
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Chemistry in embedded disks: setting the stage for planet formation
To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.
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Biomimetic Copper Catalysts for the Electrochemical Oxygen Reduction Reaction
Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.
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Meta-heuristics for vehicle routing and inventory routing problems
Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich
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Civil Liability for Damage caused by Global Navigation Satellite System
Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.
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Collaborative learning in conservatoire education: catalyst for innovation
Het doel van dit proefschrift is om eerst te onderzoeken welke vormen van samenwerkend leren bij de verschillende conservatoria in de praktijk worden gebracht, om vervolgens te kijken naar hoe samenwerkend leren kan worden geïmplementeerd.
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Benefit for all – Een ecosysteem voor een gezonde levensstijl
Het BENEFIT-programma is een publiek-privaat ecosysteem in een nationaal consortium, met als doel patiënten met cardiovasculaire aandoeningen langdurig in hun eigen thuissituatie te ondersteunen bij een gezonde leefstijl.
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Effective Protection of Fundamental Rights in a pluralist world
Welke kansen en bedreigingen vloeien voort uit de institutionele en normatieve diversiteit op het terrein van de rechten van de mens voor de effectieve bescherming van die rechten in een wereld die gekenmerkt wordt door pluralisme?
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George Miley
Wiskunde en Natuurwetenschappen
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Novel chemical tools for target validation in neuroinflammation
Stelt
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Private lessons for guitar and ukelele | English spoken
Kunst en vrije tijd, Kunst en vrije tijd
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Insolvency Close-out Netting: A comparative study of English, French and US laws in a global perspective
Op 1 december 2020 verdedigde Bernadette Muscat haar proefschrift 'Insolvency Close-out Netting: A comparative study of English, French and US laws in a global perspective'. Het promotieonderzoek is begeleid door promotoren prof.mr.drs. M. Haentjens en prof.mr. B. Wessels.
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Profinite groups with a rational probabilistic zeta function
Promotores: H.W. Lenstra, A. Lucchini
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Non-take-up of social support and the implications for social policies
This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.
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An Algebra for Interaction of Cyber-Physical Components
Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Shielding software systems: A comparison of security by design and privacy by design based on a systematic literature review
De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Novel target engagement biomarkers for better drug candidates
M van der Stelt
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Cytochrome C Oxidase mimics for use in catalytic water oxidation
Hetterscheid
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Differentiated instruction in practice: a teacher perspective
Veel docenten in het voortgezet onderwijs houden rekening met verschillen tussen leerlingen. Uit het promotieonderzoek van Saskia Stollman (ICLON) blijkt dat zij hierbij ruimte om te experimenteren en ondersteuning van de school(leiding) nodig hebben.
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A new window on the Universe
Rottgering
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Leiden University Centre for the Arts in Society
Het Leiden University Centre for the Arts in Society (LUCAS) is wereldwijd een van de weinige onderzoeksinstituten waar wetenschappers op het gebied van literatuur, beeldende kunst, architectuur, design en mediastudies samenkomen om onderzoek te doen naar de culturele productie van de westerse wereld,…
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From the Rule of Law to a Culture of Justice: a Practitioner’s Challenge to Policy Thinkers
Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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'A Healthy Diet for A Healthy Life' subsidie voor Lorenza Colzato
Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…
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industrial waste gases (mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation and coatings
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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The European Public Servant: A shared Administrative Identity?
Op dinsdag 24 maart is het boek 'The European Public Servant: A shared Administrative Identity?' verschenen.
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Squaramide-based supramolecular materials for 3D cell culture applications
A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.