Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Bijna drie miljoen Nederlanders emigreerden na de Tweede Wereldoorlog naar landen als Canada en Australië. Het voorlichtingsmateriaal van de Nederlandse overheid was dikwijls verre van objectief, constateert neerlandicus Ton van Kalmthout in zijn oratie.

Ondanks dat vrouwen in de achttiende en negentiende eeuw zeer actief waren in de literatuur, krijgen ze weinig aandacht in de canon. Hoe komt dit en wat kan eraan gedaan worden? Rick Honings, universitair docent aan het LUCAS, schreef samen met Lotte Jensen een boek over de rol van de auteur: Romantici…

Maar liefst drie interessante lezingen op onze faculteit op donderdag 8 september, en alle drie zijn ze online te volgen! Maxim Osipov, onze Russische ‘gastschrijver’, geeft zijn eerste openbare Leidse lezing, Renske Cohen Tervaert, curator bij Kröller-Müller, vertelt in de Van de Waallezing over de…

Lezing, Studium Generale

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Promotie

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

In De verwoestingen van Rusland beschrijft politicoloog Hans Oversloot (Universiteit Leiden) de uiterst turbulente geschiedenis van de Sovjet-Unie en de Russische Federatie van de afgelopen 35 jaar. Aan de orde komen onder meer de teloorgang van het socialisme door Gorbatsjov, de opkomst van de oligarchen…

Noord-Korea zou volgens Zuid-Koreaanse inlichtingen al 1500 militairen in Rusland trainen voor de oorlog in Oekraïne. Noord-Korea-deskundige Remco Breuker van de Universiteit Leiden geeft in diverse media zijn visie op deze ontwikkeling.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

From the 1920s on, popular music in Southeast Asia was a mass-audience phenomenon that drew new connections between indigenous musical styles and contemporary genres from elsewhere to create new, hybrid forms. This book presents a cultural history of modern Southeast Asia from the vantage point of popular…

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

De Faculteit der Rechtsgeleerdheid deelt met trots mee dat Professor Ann Skelton, hoogleraar Kinderrechten in een duurzame wereld en voorzitter van het Kinderrechtencomité van de Verenigde Naties, een eredoctoraat is toegekend door de University of Strathclyde. Deze prestigieuze erkenning is een eerbetoon…

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

De master Neerlandistiek / Dutch Studies geeft je een stevige basis voor een (inter)nationale loopbaan op het gebied van Nederlandse taal en cultuur. Of je nu het bedrijfsleven in wil, het onderwijs, bij de overheid wil werken of wetenschappelijk onderzoek wil gaan doen: deze master biedt verschillende…

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Due to the almost complete disappearance of the archive of the Old Dutch West India Company (WIC, 1621-1674) not much is known about the ships and crews of this company. In this project we start the reconstruction of this basic information making use of new digital humanities techniques to extract this…

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

De master Neerlandistiek: Moderne Nederlandse letterkunde is een eenjarige opleiding waarin je 60 ECTS behaalt. Je kiest je eigen vakken, zolang dit past binnen de programmastructuur van de opleiding.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Data theory research on the analysis on the multidimensional data

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.