Promotor: K.E. Schalm, Co-promotor: S.S. Lee

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

Promotor: Prof.dr. B. van de Water

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

This dissertation presents new cryptographic protocols, which can be divided into two families.

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: B. van de Water

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Van alle papyri en andere objecten uit de collectie van het Leids Papyrologisch Instituut zijn digitale opnames gemaakt die worden gebruikt voor onderzoek, onderwijs en ontsluiting van de collectie voor een groter publiek.

Wij verrichten onderzoek op onder meer het terrein van het rechtspersonen- en vennootschapsrecht en het insolventierecht.

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Eduard Fosch-Villaronga, universitair hoofddocent bij eLaw, heeft bijgedragen aan 'Cyber–Physical–Human Systems', een boek waarin de nieuwste ontwikkelingen in interacties tussen cyberfysische systemen en mensen worden onderzocht.

Healthcare robots and AI is een onderzoek naar juridische en reguleringsaspecten van robots en kunstmatige intelligentie in de zorg.

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

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Op vrijdag 24 maart aanstaande zal Prof. Amanda Perry–Kessaris (Kent Law School) de maandelijkse Leiden Socio-Legal Lecture verzorgen.

How to contribute to a quantum leap of eco-industrial symbiosis in China?

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

INFORM (Introduction of the data protection reform to the judicial system) is een project dat door het Directoraat-Generaal Justitie and Consumentenzaken van de Europese Commissie wordt gefinancierd.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…