555 zoekresultaten voor “life neandertals and first anatomically modern human” in de Publieke website
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multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
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Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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Impacts of the use of Natural Resources and Products
Development of an aggregated impact indicator to measure decoupling.
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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Agression and emotions
Cultural and individual differences
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Galois representations of elliptic curves and abelian entanglements
Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)
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Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration
Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.
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reductions in the speed of sound of the inflaton in cosmological data, and other topics
Promotor: Prof.dr. A. Achucarro
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Combining classic and novel tools in the study of Historical Collections of Chinese Materia Medica in the Netherlands
Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…
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Private lessons for guitar and ukelele | English spoken
Kunst en vrije tijd, Kunst en vrije tijd
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Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Publicatie Helen Duffy over Global Trends in Counter-terrorism and the Implications for human rights in Africa
Op 8 maart 2023 verscheen een monografie over Global Trends in Counter-terrorism and the Implications for human rights in Africa. Deze studie van Helen Duffy, hoogleraar Internationaal Humanitair Recht en Mensenrechten in Leiden, onderzoekt de impact van terrorismebestrijding op democratie, vrede, rechtsstaat…
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mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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The astrochemical factory: A solid base for interstellar reactions
In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.
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Chemistry in embedded disks: setting the stage for planet formation
To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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microbially-colonized hosts: Microbiota-mediated physisorption interactions and particle-specific toxicity
The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.
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Poiesis and the Performance Practice of Physically Polyphonic Notations
Kevin speelt hedendaags repertoire dat zich onderscheidt doordat de lichamelijk handelingen die nodig zijn om deze muziek uit te voeren in de notatie van elkaar losgekoppeld zijn. Dit heet ook wel physical polyphonic notations, een unieke en relatief recente trend in de muziek waarbij naast de noten…
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Een gedreven buitenstaander: J.H. van 't Hoff de eerste Nobelprijswinnaar voor Scheikunde
This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…
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Co-benefits & Co-damages of environmental policies related to climate change and long-range transboundary air pollution
Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.
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intermediates for polyurethane plastics for rigid foams/building insulation and coatings
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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The Sand Motor - Building with Nature to optimise coastal protection and other ecosystem services
How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?
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2 Assistant Professors in Intelligence and Security (1 fte)
Governance and Global Affairs, Institute of Security and Global Affairs, Intelligence and Security
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RiskCycle: Risk-based management of chemicals and products in a circular economy at a global scale
How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?
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Judith Pollmann
Faculteit der Geesteswetenschappen
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World Archaeology
De onderzoekers van het departement ‘World Archaeology’ van de Faculteit Archeologie richten zich in hun onderzoek op verschillende periodes en regio’s: van de oorsprong van de mens tot aan de Middeleeuwen en de moderne tijd, en van Azië tot Zuid-Amerika.
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Research Seminar: Between Myth and Reality: Rules Of Observance As Texts Of Life In The High Middle Ages (RUG, 11 March 2024)
On the occasion of the appearance of the monograph "Varieties of the Self.Peter Abelard and the Mental Architecture of the Paraclete" written by Babette Hellemans and published at Brill in 2023, a workshop will be organized concerning rules of observance as ‘texts of life’ in ascetic communities. The…
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ReCiPe
The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Lecturer positions (0.6-1.0 FTE) in Computer Science, Machine Learning, and AI
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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‘The ILLP has been helpful for every human relation I have’
What is leadership? Can it be taught, and if so, how? The International Leiden Leadership Programme (ILLP) helps students find their own style, say ILLP graduate Marko Simovski and his former coach Annah Neve in an interview: 'It’s about you, discovering you.'
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Shekhar Kolipaka
Faculteit der Sociale Wetenschappen
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
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Andrea Evers over placebo-effect en conditionering
Het eerste wereldwijde congres over placebostudies van 2-4 april moest uitwijken naar de Stadsgehoorzaal om de deelnemers uit 20 landen te ontvangen. Ook de Nederlandse media lieten zich niet onbetuigd. Bekijk een selectie uit het nieuws met Andrea Evers over placebo's en conditionering.
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Data-Driven Risk Assessment in Infrastructure Networks
Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'
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Aspects of cosmic acceleration
The focus of the dissertation
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Natalya Tsoy
Wiskunde en Natuurwetenschappen
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Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Mingming Hu
Wiskunde en Natuurwetenschappen
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Publicatie artikel “Social support at work and at home: Dual-buffering effects in the work-family conflict process”
Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP) in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of Western…
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BioSustain
Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.