In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Vrijdag 28 oktober 2016 vond op de Raad van State het symposium ‘De gevolgen van privatisering en liberalisering voor de rechtsbescherming door de bestuursrechter’ plaats. De Afdeling Staats- en bestuursrecht van de Universiteit Leiden en de Raad van State organiseerden gezamenlijk dit symposium, ter…

De discussie over de sluiting van illegale schietbanen van Defensie, als gevolg van de stikstofwetgeving is ingewikkeld en omvat diverse juridische aspecten. Armin Cuyvers, hoogleraar Europeesrecht, bespreekt de zaak in BNR-Nieuwsradio.

Van 26 t/m 30 juni 2017 organiseert de afdeling Staats- en Bestuursrecht van de Universiteit Leiden een zomercursus over de Europeanisering van het nationaal bestuursrecht in de lidstaten van de Europese Unie.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: B. van de Water

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Promotor: B. van de Water

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Het programma ‘uNMR-NL’, een project om een 1.2 GHz NMR spectrometer in Nederland te plaatsen voor chemisch onderzoek, heeft 18,5 miljoen euro ontvangen om deze grootschalige faciliteit op te zetten. Dit wordt vanmiddag in Utrecht bekend gemaakt door staatssecretaris Zijlstra van OCW en Jos Engelen,…

Dr. Bela Bode ontvangt van de Alexander von Humboldt-stichting de Feodor Lynen onderzoeksbeurs voor de ontwikkeling van nieuwe methoden voor verbetering van het signaal in de vaste stof NMR. Hij streeft naar een specifiek analytisch instrument voor oppervlakte-studies en onderzoek over membranen en…

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Onderzoek aan het Leids Instituut voor Onderzoek in de Natuurkunde (LION) is fundamenteel en nieuwsgierigheids-gedreven. Al onze wetenschappers delen de wens om de kennis van de wereld om ons heen te vermeerderen, in een open, nieuwsgierige sfeer, waarin innovatieve ideeën ontstaan die toepassingen…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: Roeland M.H. Merks

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.