The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Promotor: W. Jiskoot, Co-promotor: A. Kros

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotor: A.P.IJzerman Co-promotor: A. Bender

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

BRAIN Biotech en het Instituut Biologie Leiden (IBL) van Leiden Universiteit gaan samen een Aspergillus schimmelstam verder ontwikkelen. Deze zal in staat zijn meer te produceren en daarmee een biologische circulaire economie stimuleren. De samenwerking is gebaseerd op BRAINs moleculaire hulpmiddel…

Hoe ontwikkelde het Nederlandse vluchtelingenbeleid zich in een periode waarin opeenvolgende coalitiekabinetten verantwoordelijk waren voor dit beleid tijdens vluchtelingencrises tussen 1913 en 2017, en welke overwegingen kunnen deze ontwikkeling verklaren?

Langdurige ziekten bestrijden door organen, weefsels en cellen te repareren.

Didactiek

Kunst en vrije tijd, Kunst en vrije tijd

Promotie

Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…

Engels in perspectief

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Promotores: H. Schiessel, G.T. Barkema

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: A. Kros

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: T. Schmidt

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: Prof.dr. B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Supervisor: P.J.J. Hooykaas

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.