844 zoekresultaten voor “stam cell differentiatie” in de Publieke website
-
Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
-
Squaramide-based interpenetrated networks for load-bearing applications
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.
-
Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
-
Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
-
Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
-
Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
-
Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
-
Applications for DNA-encapsulated silver clusters in physics, biology and medicine
We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.
-
The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
-
Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
-
Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
-
Single-cell immune profiling of atherosclerosis
Promotie
-
Immune cell networks in Inflammatory Bowel Disease
Promotie
-
How costimulation directs regulatory T cell responses
Promotie
-
Exploring and exploiting CD8+ T cell proliferation
Promotie
-
Click to Release for Immunce Cell Activation
Promotie
-
Red cell transfusion in critically ill patients
Promotie
-
Instituut voor Metajuridica
De rechtswetenschap is een verzamelnaam voor de 'juridica' en 'metajuridica'.
-
Nederland en vluchtelingen: de politiek-bestuurlijke geschiedenis van de strijd tussen controle en humaniteit tijdens vluchtelingencrises tussen
Hoe ontwikkelde het Nederlandse vluchtelingenbeleid zich in een periode waarin opeenvolgende coalitiekabinetten verantwoordelijk waren voor dit beleid tijdens vluchtelingencrises tussen 1913 en 2017, en welke overwegingen kunnen deze ontwikkeling verklaren?
-
Regeneratieve geneeskunde
Langdurige ziekten bestrijden door organen, weefsels en cellen te repareren.
-
Korte intensieve sessie over onderwijsontwikkeling
Didactiek
-
Engels
Engels in perspectief
-
Biologie
Biologie in perspectief
-
Integration and disentanglement of single-cell and spatial transcriptomics with applications in Autosomal Polycistic Kidney Disease
Promotie
-
Hoe uitzaaiende tumoren hun omgeving naar hun hand zetten
Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…
-
Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
Promotie
-
Donor T-cell responses and interaction with graft versus host target tissue after allogeneic stem cell transplantation
Promotie
-
Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
-
Natuurkunde in beeld: kankercellen als een explosie van vuurwerk
Denk jij bij natuurkunde alleen aan ingewikkelde formules? Dan ben je niet de enige. Daarom organiseert het Leids Instituut voor Natuurkunde elk jaar de LION Image Award om een andere kant van natuurkunde te laten zien: mooie beelden over intrigerende wetenschap. De winnaar van de fotowedstrijd van…
-
Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
-
Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
-
Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
-
Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
-
Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
-
Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
-
The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
-
The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
-
The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
-
Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
-
Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
-
In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
-
Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
-
Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
-
PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
-
Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
-
Surviving embryogenesis: The extraembryonic serosa protects the insect egg against desiccation and infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee
-
Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
-
Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.