Due to the almost complete disappearance of the archive of the Old Dutch West India Company (WIC, 1621-1674) not much is known about the ships and crews of this company. In this project we start the reconstruction of this basic information making use of new digital humanities techniques to extract this…

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Data theory research on the analysis on the multidimensional data

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Promotor: H.J.M. de Groot

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr. L.J. Slikkerveer

This thesis describes a study from both a theoreticaL and an experimental point of view.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Sustainable energy from wind and solar is most readily available near the sea.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Electron microscopy has become an extremely important techniquein a wide variety of elds.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.

Congres/symposium

Promotie

Promotie

Promotie

Promotie

Promotie

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Contributions to the UNEP international panel for sustainable resource management

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Leiden University’s Academic Challenge

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.