Promotor: V. Vitelli, Co-promotor: J. Paulose

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Consequences for sediment stability and seston trapping

Promotores: Wim Jiskoot; Ferry Ossendorp

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Cardiovascular disease is the leading cause of death worldwide.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Cardiovascular syndromes are the major cause of death in Western societies.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

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Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Promotor: Prof.dr. M. Danhof

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. M. Ubbink

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

De politicologen Marijn Nagtzaam (Universiteit Leiden) en Patrick van Erkel (Universiteit van Antwerpen) testen hoe bepaalde opties die kiezers hebben op het stembiljet hun stemgedrag beïnvloeden, met name voor het stemmen op personen.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Promotores: W. Jiskoot, F. Ossendorp

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt