Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotores: Wim Jiskoot; Ferry Ossendorp

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Cardiovascular disease is the leading cause of death worldwide.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

Promotor: Prof.dr. C.W.J. Beenakker

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Cardiovascular syndromes are the major cause of death in Western societies.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

De meeste kinderen leren pas op de middelbare school Frans. Hoe leuk is het als ze al wat Franse woorden leren en kennismaken met de Franse cultuur op de basisschool? Dat kan via deze kennismakingslessen, gemaakt door studenten van de Universiteit Leiden.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Fundamental research in the ALgebra, Geometry And Number Theory

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. S.F. Portegies Zwart

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: F. Arbab

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel