1,434 zoekresultaten voor “computer ahmed drug design” in de Publieke website
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Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
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Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Computer Science op 51e plaats in QS World Universities Ranking 2011
Computer Science op 51e plaats in QS World Universities Ranking 2011
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Informatica
Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Rebekah Tromblé
Students Practicing Citizen Journalism
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Technologie in onderwijs
Laat je op deze pagina inspireren door best practices van onderwijsvernieuwende voorbeelden die in ons onderwijs invulling geven aan de ambitie Technologie in onderwijs.
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Jaap van den Herik vertelt op BNR Nieuwsradio over computers en intuïtie
In de toekomst kunnen computers hun beslissingen baseren op intuïtie. Dat stelde Jaap van den Herik, directeur van het Leiden Centre of Data Science, afgelopen vrijdag tijdens zijn afscheidsrede als hoogleraar aan Tilburg University. In een interview met BNR Nieuwsradio onderbouwt hij zijn stelling.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters
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Mario van der Stelt
Wiskunde en Natuurwetenschappen
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Roxanne Kieltyka
Wiskunde en Natuurwetenschappen
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Simona Demková spreekt op 2024 Computers, Privacy and Data Protection (CPDP) Conference
Op de 2024 Computers, Privacy and Data Protection (CPDP) conferentie die tussen 22 en 24 mei in Brussel plaatsvond, was een presentatie te zien van Simona Demková van het Europa Instituut van de Universiteit Leiden.
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LTA lunchlezing: Designing individualized learning - the case of Digital Humanities
Lezing
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Guiding safe and sustainable technological innovation under uncertainty: a case study of III-V/silicon photovoltaics
A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Mark Roelofsen
Faculteit Governance and Global Affairs
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Cleared for take-off, Game-based learning to prepare airline pilots for critical situations
Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.
- Drugs & geschiedenis
- Drugs & medicijnen
- Drugs & biologie
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Hora Est via de computer: zo verliep de eerste volledig digitale promotie in Leiden
Samineh Bagheri is de eerste PhD-kandidaat die haar proefschrift volledig op afstand verdedigt.
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Changing the Nature of the Beast
Op de eerste dag van jouw nieuwe baan heb je zweethanden, ben je nerveus en onzeker, maar een paar maanden later zijn die gevoelens al weer verdwenen. Je hebt jouw nieuw rol eigen gemaakt en je bent nu onderdeel van de organisatie. Het proces dat daar naar toe leidt heet
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Studieprogramma
Je volgt een basispakket van biologievakken, exacte vakken in de informatica en speciale integratievakken.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Dr. Tom Wennekes wint Farmacochemieprijs
Tijdens de jaarlijkse Wetenschappelijke Dag van de Sectie Farmacochemie van de KNCV in Weesp werd de Nederlandse Farmacochemieprijs uitgereikt aan Dr. Tom Wennekes, voor zijn proefschrift, getiteld: ‘Lipophilic iminosugars: synthesis and evaluation as inhibitors of glucosylceramide metabolism’.
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Eduard Fosch Villaronga
Faculteit Rechtsgeleerdheid
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Planning
Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.
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Instituut voor Informatica aan de Universiteit Leiden
Leiden Institute of Advanced Computer Science (LIACS)
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Joni Reef
Faculteit Rechtsgeleerdheid
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Kunstmatige intelligentie en machine learning
Computers zijn in staat om ongelooflijk nauwkeurige voorspellingen te doen op basis van machine learning. Met andere woorden, deze computers kunnen zonder tussenkomst leren als ze eenmaal door mensen zijn voorgeprogrammeerd. Bij LIACS verkennen en verleggen we de grenzen van wat een revolutionaire nieuwe…
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
- Drugs & kunst/literatuur
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Marcello Bonsangue
Wiskunde en Natuurwetenschappen
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Unieke medicijnstructuren vinden met kunstmatige intelligentie en scheikunde
In de zoektocht naar nieuwe medicijnen tegen onder andere kanker heeft een Leids team een nieuwe werkwijze ontwikkeld. Dit stappenplan combineert kunstmatige intelligentie (AI) met moleculair modelleren en is geschikt om onbekende en vernieuwende medicijnstructuren te vinden, zo bewezen de onderzoek…
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.