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Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Promotie

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Promotor: Prof.dr. T. Hankemeier

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: Prof.dr. P.C. van Welzen

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Promotor: M. Ubbink, Co-promotor: G. Siegal

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Het onderwerp van dit proefschrift is integratie van klinische kennis en kennis van de basisvakken in het medisch onderwijs en de rol die concept maps kunnen spelen in het expliciet maken van deze zogenoemde verticale integratie.

This thesis presents the anharmonic infrared spectra of a series of polycyclic aromatic hydrocarbons. Comparisons and characterizations are made based on high-resolution low-temperature gas-phase experimental spectra.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Deze opleiding biedt de mogelijkheid om biologie-onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid om sterrenkundig onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid om top onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid top onderzoek in de natuurkunde te combineren met ondernemerschap, technologie management, innovatiebeheer en besluitvorming in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid top onderzoek in de wiskunde te combineren met ondernemerschap, technologie management, innovatiebeheer en besluitvorming in het bedrijfsleven.

In het programma ‘Verder met publiek leiderschap’ werken het Leiden Leadership Centre van de Universiteit Leiden en verschillende publieke organisaties samen om leiderschap goed te onderzoeken en verder te ontwikkelen. Leiderschapsontwikkeling wordt daarmee evidence-based en wetenschappelijk onderzoek…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).