Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

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This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotie

The NWO-funded Vidi project “American foreign policy and liberalism” challenges the idea that the United States has created and sustained a “liberal international order” since World War II. It instead explores the ways in which illiberal ideologies – such as those underpinning racial hierarchy at home…

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Promotor: Prof.dr. S. Portegies Zwart

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: Prof.dr. T.H.W. Bäck

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: A.P. IJzerman

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

We consider the propagation of electrical signals through nerve fibres.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.