Promotor: B. van de Water

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Op 25 november 2020 verdedigde Sara Arendse haar proefschrift 'De uiterlijke verschijningsvorm in het strafrecht'. Het promotieonderzoek is begeleid door promotoren prof.mr. C.P.M. Cleiren en prof.mr. J.M. ten Voorde.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

De Universiteit Leiden vierde op 8 februari 2024 haar 449ste stichtingsdag.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: B. van de Water

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Zojuist verschenen: Nederlands internationaal privaatrecht Special issue: Private international law and finance

In dit artikel analyseren Lydie Cabane en Martin Lodge analyseren de invloed van institutionele keuzes op het aanpassen van beleidsintegratie in grensoverschrijdende crisisbeheersing.

Stimuleren van Prestaties en Motivatie in de Eerste Jaren van het Voortgezet Onderwijs

Promotie

Dit artikel onderzoekt de clusters van crisiscommunicatieonderzoek in de literatuur, waarbij overlappingen en raakvlakken tussen verschillende vakgebieden worden onderzocht.

Welke categorieën bestaan er in de talen van herders? Reflecteren deze semantische concepten universele of taalspecifieke tendensen? Wat (omgeving? cultuur?) bepaalt de overeenkomsten (of de verschillen) die crosslinguïstisch worden aangetroffen in veekleursystemen?

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Roeland M.H. Merks

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: J. Kuiper

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.