The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: S.M. Verduyn Lunel

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

De Tweede Kamerverkiezingen die staan gepland voor maart 2017 zullen resulteren in een versnipperd parlement en een lastige kabinetsformatie, aldus de politicoloog Hans Vollaard (Universiteit Leiden) in een bijdrage aan het EUROPP-blog.

Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

De Amerikaanse inlichtingendiensten brachten president Nixon ten val, en niet de media zoals het algemene beeld is. Andrew Gawthorpe, onderzoeker op het gebied van diplomatie en de Amerikaanse buitenlandpolitiek, hoopt dat de inlichtingendiensten onder Trump ook de juiste keuze maken.

How to contribute to a quantum leap of eco-industrial symbiosis in China?

Overzicht van economische vakken per opleiding, zoals aangeboden door de Afdeling Economie.

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

What is movements and corridors of the Bornean pygmy elephant in Sebuku forest? What is the nature of human-elephant conflict in Nunukan District in time and space? What are the diets of the Bornean elephants related to crop raiding?

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Publicaties die verschijnen in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus.

De politicologen Joop van Holsteyn en Tom Louwerse (Universiteit Leiden) zien dat referenda in Nederland de Euroscepsis een stem geven. Maar van een ‘Nexit’ is nog lang geen sprake.

Effectiveness and Side-effects.

Overzicht van de vacatures bij de afdeling Economie.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Governance and Global Affairs, Institute of Security and Global Affairs