538 zoekresultaten voor “molecular genetica” in de Publieke website
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Characterization of DNA-replication proteins and their molecular mechanisms
Promotie
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Contextual glucocorticoid signaling in-vivo: A molecular perspective
Promotie
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
Promotie
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
Promotie
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Updates in Molecular Diagnosis and Targeted Treatment of Thyroid Neoplasia
Promotie
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Benodigde documenten
Om je aan te melden voor de bacheloropleiding Molecular Science and Technology heb je meerdere documenten nodig. Zorg ervoor dat je deze documenten bij de hand hebt.
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Bayesiaanse statistiek in oneindig veel dimensies
De statistiek van grote datasets, zoals in de genetica en bij medische scans, is nog volop in ontwikkeling. Hoe haal je de beste informatie uit zulke rommelige data? Wat zijn reële foutmarges?
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Latijns-Amerika
Leidse experts van Latijns-Amerika hebben specialismes zoals talen, culturen, antropologie, archeologie, geschiedenis, filosofie en genetica. Samen proberen zij de mysteries en het verborgen verleden van het Amerikaanse continent te ontdekken.
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Esther van der EntWiskunde en Natuurwetenschappen
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Emilie DidaskalouWiskunde en Natuurwetenschappen
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Probing Molecular Layers with Low-Energy Electrons
Promotie
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
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The role of water in hydrogen electrocatalysis
Promotor: M.T.M. Koper, Co-promotor: L. Juurlink
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Control of Western flower thrips through jasmonate-triggered plant immunity
We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.
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Systematics and Biogeography of the Dissochaeta alliance (Melastomataceae)
Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.
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The structure of the cytochrome P450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography
Promotor: Prof.dr. M. Ubbink
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Proefstuderen LST
Studievoorlichting
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
Promotie
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Unfolding the principles of genome folding and dynamics in bacteria
Remus Dame
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Eregalerij 2022
In 2022 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
Promotie
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Synthetic peptides, nucleic acids and molecular probes to study ADP- ribosylation
Promotie
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Elucidation of the molecular alterations underlying aging-associated muscle wasting by applying multi-omics
Promotie
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Molecular sensors for calcium ion detection via triplet-triplet annihilation upconversion
Promotie
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Medical Delta professor Eline Slagboom: 'In de delta-regio komt alles samen'
Al meer dan twintig jaar bestudeert Eline Slagboom meerdere generaties van families. Daarmee verzamelt ze data over waarom sommige mensen gezond oud worden en anderen al vroeg achteruitgaan. Met deze kennis kun je nauwkeuriger iemands biologische leeftijd vaststellen en de best passende individuele…
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Towards Photocatalytic Water Splitting in Homogeneous Solutions Using Molecular Metalloporphyrin Photosensitizers and Catalysts
Promotie
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The dust and molecular gas in the torus of NGC 1068
Promotie
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Decoding the molecular makeup of the human ovary through single-cell transcriptomics
Promotie
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The development of molecular tools for investigating NAD+ metabolism and signalling
Promotie
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Molecular imaging of pancreatic and rectal cancer - Towards optimized detection and response prediction
Promotie