464 zoekresultaten voor “middle allows” in de Publieke website
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Beschadigd vertrouwen
Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Geometry of Vegetation Pattern
One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Graphene at fluidic interfaces
In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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Understanding deep meta-learning
The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.
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Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
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Constraint-Based Analysis of Business Process Models
Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Safe anytime-valid inference: from theory to implementation in psychiatry research
Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Principal algebraic actions of the discrete Heisenberg group
Promotor: Prof.dr. W.T.F. den Hollander
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Regulation of the arabidopsis AGC kinase PINOID by PDK1 and the microtubule cytoskeleton
Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Exiopol
A new environmental accounting framework using externality data and input-output tools for policy analysis.
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Resolving gas-phase metallicity in galaxies
Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
- Seminar 4: The Formation of Discourse Communities in the Early Middle Ages
- International conference: Patristic Sermons in the Middle Ages: Collections, Mediators and the Practice of Compiling
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Baris Ates in Trouw over censuur in De goddelijke komedie van Dante
De Nederlandse uitgeverij Blossom Books heeft besloten om aanpassingen aan te brengen in De goddelijke komedie van Dante. Dat roept verontwaardiging op volgens student Midden-Oosten Studies Baris Ates.
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The Transformation of Science Systems in the Middle East and North Africa
Promotie
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Vroegste handschriftcollecties uit het Midden-Oosten in Leiden nu beschikbaar in Open Access
Enkele van de belangrijkste handschriftencollecties uit de Bijzondere Collecties van de Universitaire Bibliotheken Leiden (UBL), bestaande uit 443 uiterst zeldzame en vaak unieke banden, zijn in Open Access beschikbaar gesteld via Digital Collections. De beschikbare handschriftcollecties omvatten de…
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Leidse wetenschappers maken Ted Ed-video’s: ‘We willen de islamitische geschiedenis integreren in de wereldgeschiedenis’
Hoe is het Islamitische Rijk ontstaan? En hoe was het dagelijks leven daar? Twee nieuwe Ted Ed-animaties geven in eenvoudige taal het antwoord op die vragen. Arabisten Petra Sijpesteijn en Birte Kristiansen vertellen hoe het was om de video’s te ontwikkelen.
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Blindengeleidehonden: een allesbehalve moderne uitvinding
Lange tijd dachten zelfs veel onderzoekers dat de blindengeleidehond een vrij moderne uitvinding was. Rondneuzend in archiefmateriaal ontdekte universitair docent Krista Milne bij toeval dat blindengeleidehonden hun blinde baasjes al in de middeleeuwen hielpen. Milne heeft nu een NWO-XS-subsidie ontvangen…
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Distant star formation in the faint radio sky
One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.
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Schouwburgstraat Community Garden
In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.
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Empirical signatures of universality, hierarchy and clustering in culture
In this thesis,
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Global Fields and Their L-functions
Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.
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Surveying young stars with Gaia: Orion and the Solar neighbourhood
OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Growth and Transport properties of (Rare Earth)TiO3 / SrTiO3 interfaces
This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.