Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotores: T.H. Oosterkamp, N. de Jonge

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

De data-economie is gebaseerd op het verzamelen en verwerken van grote hoeveelheden gegevens over consumenten en hun gedrag. Zulke gegevens worden gebruikt om winstmarges te optimaliseren met behulp van (dynamische) prijsdifferentiatie voor verschillende consumenten.

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

Nature, nurture and neural mechanisms of social emotion regulation in childhood

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

We are excited to share that the article, Does pre‐packed bankruptcy create value? An empirical study of post-bankruptcy employment retention in The Netherlands, by our colleagues, Jan Adriaanse, Jean-Pierre van der Rest, Gert-Jan Boon, and Reinout Vriesendorp, published in the International Insolvency…

De moderatoren en voorzitters van de ECPR hebben de winnaars bekend gemaakt van de Best Paper Awards.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: Prof.dr. G.J. Kroes

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotores: G.A. Persoon, H.H. de Iongh

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Op 23 april verdedigde Rowie Stolk het proefschrift 'Procederende belangenorganisaties in de polder: een interdisciplinair perspectief op de toegang tot de rechter'. Het promotieonderzoek is begeleid door Ymre Schuurmans en Jerfi Uzman.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Bij Psychologielab op Wielen nemen we je privacy en de veiligheid van je persoonlijke gegevens zeer serieus. We willen je verzekeren dat alle informatie die tijdens dit onderzoek wordt verzameld, zal worden behandeld in overeenstemming met de General Data Protection Regulation (GDPR).

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

Wil je deelnemen aan ons onderzoek in Psychologielab op Wielen? Momenteel hebben we twee experimenten in de bus. Natuurlijk zorgen we voor de bescherming van je gegevens en privacy. Doe mee met onze experimenten en meld je aan.

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

Het onderzoek dat binnen het Hazelhoff Centre for Financial Law wordt verricht, richt zich op het financieel recht in brede zin.

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

The ultimate aim of this project is to improve cooperation between courts in different Member States.

Hoe kunnen we kwaliteit van leven en studiesucces vergroten bij jonge, hoog-functionerende volwassenen met autisme?

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.

Mensenrechten zijn lang het unieke domein van staten geweest. Dat is veranderd met de globalisering en de opkomst van multinationale ondernemingen. De zorg voor fundamentele arbeidsrechten binnen mondiale toeleveringsketens vormt een probleem.