503 zoekresultaten voor “indigenous people presented” in de Publieke website
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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It's just a phase: High-contrast imaging with patterned liquid-crystal phase plates to facilitate characterization of exoplanets
This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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The Weight of Nations
Material outflows from industrial economies.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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De verzamelwoede van Martinus van Marum (1750-1837) en de ouderdom van de aarde
Promotor: F.J. van Lunteren, E. Jorin
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Ice and Gas in Protostellar Clouds and Planet-forming Disks
This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
- Presenting Medieval Research (5 ECTS)
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Ecology of the Ethiopian wolf in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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Empathic or anxious mistakes?
A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
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Understanding the ecology of the Bornean Pygmy Elephant (Elephas maximus borneensis) in the Sebuku Forest, Nunukan District, North Kalimantan
What is movements and corridors of the Bornean pygmy elephant in Sebuku forest? What is the nature of human-elephant conflict in Nunukan District in time and space? What are the diets of the Bornean elephants related to crop raiding?
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Synergy Study: Sentinel2 –Sentinel3 Land Products
To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Afdeling Industriële Ecologie (CML-IE)
The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.
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Network analysis methods for smart inspection in the transport domain
Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.
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The Agta of the Northern Sierra Madre. Livelihood strategies and resilience among Philippine hunter-gatherers
Promotores: G. Persoon, R. Schefold
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Information Diffusion Analysis in Online Social Networks based on Deep Representation Learning
With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.
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A Manifesto for Investigating the Impacts of Object Flows on Past Societies: Objectscapes
World history is often framed in terms of flows of people and migration: humans coming ‘out of Africa’, the spread of farmers in the Holocene, Phoenician and Greek diasporas over the ancient Mediterranean, the colonization of the world by Europeans from the 16th century onwards. Together with his Exeter…
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Building Bridges for Meaningful eHealth: aligning people, technology and practice through collaboration and knowledge sharing
Promotie
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Sheltering 10 billion people in a warming and resource-scarce world: challenges and opportunities
Promotie
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Insolvency Office Holder-project
It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.
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Structured Parallel Programming for Monte Carlo Tree Search
The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.
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Staatscommissies/State committees
In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…
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Evaluating Asian aquaculture using Life Cycle Assessment (LCA)
Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?
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New Foundations for Separation Logic
The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?
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Onderzoekers
In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.
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Extra uitdaging
Bij de Universiteit Leiden krijg je de mogelijkheid om het beste uit jezelf te halen. Heb je tijd en talent? Dan is honoursonderwijs iets voor jou. Of doe een bestuursjaar.
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Quantification of ecosystem services within river catchments
How can ecosystem services within river catchments be quantified in spatial and temporal explicit way?
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De bom (najaar 2020)
75 jaar na Hiroshima en Nagasaki In samenwerking met Japanmuseum SieboldHuis, naar aanleiding van de tentoonstelling aldaar.
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An introduction to life-story writing (English spoken)
Kunst en vrije tijd, Kunst en vrije tijd
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Parttime programma
Sinds 2021 is de master ook in deeltijd te volgen, een parttime opleiding van 2-3 dagen per week, waarvan één vaste, verplichte dag op vrijdag.
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The urge to collect
Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?
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Deep learning for visual understanding
With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.
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Aspecten van Joods leven in Roermond en Midden-Limburg 1275-2018
Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Biomimetic Copper Catalysts for the Electrochemical Oxygen Reduction Reaction
Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.