Op 14 oktober 2021 is het publieksboek uitgekomen. Sindsdien kunnen alle bestanden en links via deze website geraadpleegd worden.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotor: M. Ubbink, Co-promotor: G. Siegal

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

In Europe a number of production and communication strategies have long tried to establish local products as resources for local development. At the foot of the Alps, this scenario appears in all its contradictions, especially in relation to cheese production. The Heritage Arena focuses on the saga…

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

This book aims to be a point of reflection and debate for journalists, academics and students to recognize a fundamental task in the duty of the communications professional, which is to influence through their daily work and their routines in order to achieve a more inclusive and plural society, through…

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

Zelfredzaamheid en sociale bescherming over de levenscyclus

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Van onderwijs tot een verrijkende ervaring

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.

Writing an operational guide to the ISO standards for LCA and related sub-projects.

Students Practicing Citizen Journalism

How can we quantify the density of species within a community through environmental DNA concentrations?

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

How do nanoparticles bioaccumulate and biodistribute in organisms?

Wat zijn de gevolgen van maatschappelijke trends zoals vergrijzing, individualisering en internationalisering voor regelgeving en instituties op het terrein van sociale zekerheid, pensioenen en de arbeidsmarkt?

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk