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676 zoekresultaten voor “diagnostics and treatment” in de Publieke website

• Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists Onderzoeksoutput

  Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

• Knowledge of Medicinal, Aromatic and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical System in Pirgos and Praitoria for Community Health Onderzoeksoutput

  Promotor: Prof.dr. L.J. Slikkerveer

• Pharmaceutical Aspects of Subvisible Particles in Protein Formulations Onderzoeksoutput

  Promotor: W. Jiskoot, Co-promotor: A. Hawe

• Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance Onderzoeksoutput

  Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

• bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine receptor Onderzoeksoutput

  G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

• Image analysis for gene expression based phenotype characterization in yeast cells Onderzoeksoutput

  Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

• Microengineered Human Blood Vessels For Next Generation Drug Discovery Onderzoeksoutput

  Heart failure is a major health care problem with high mortality.

• Mechanisms of Ewing sarcoma metastasis Onderzoeksoutput

  Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

• Uncovering vulnerabilities in triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

• B cell modulation in atherosclerosis Onderzoeksoutput

  Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

• Chemical tools to monitor and control proteasome activities Onderzoeksoutput

  Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

• Semisynthetic glycopeptide antibiotics Onderzoeksoutput

  Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

• Pulling the strings on anti-cancer immunity Onderzoeksoutput

  Promotores: J. Jonkers, K.E. de Visser

• Carcinogenicity of insulin analogues Onderzoeksoutput

  Promotor: Prof.dr. B. van de Water

• Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches Onderzoeksoutput

  Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

• Exploring chemical space in covalent and competitive glycosidase inhibitor design Onderzoeksoutput

  Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

• Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches Onderzoeksoutput

  Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

• Development of life cycle assessment for residue-based bioenergy Onderzoeksoutput

  Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

• The role of zebrafish larvae for studying anxiety-like behaviour Onderzoeksoutput

  The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

• Ruthenium-peptide conjugates for targeted phototherapy Onderzoeksoutput

  As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

• Modulation of plant chemistry by rhizosphere bacteria Onderzoeksoutput

  Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

• From midplane to planets : the chemical fingerprint of a disk Onderzoeksoutput

  This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

• Dosing considerations for preterm neonates: from pharmacometrics to clinical practice Onderzoeksoutput

  Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

• Metabolomic characteristics of Catharanthus roseus plants in time and space Onderzoeksoutput

  Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

• Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases Onderzoeksoutput

  Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

• study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis Onderzoeksoutput

  Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

• Sensing Transport Onderzoeksoutput

  Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

• Novel detectors and algorithms for electron nano-crystallography Onderzoeksoutput

  Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

• arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis Onderzoeksoutput

  Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

• Development of kinase inhibitors and activity-based probes Onderzoeksoutput

  Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

• Discovery of selective diacylglycerol lipase β inhibitors Onderzoeksoutput

  Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

• Bioengineering and biophysics of viral hemorrhagic fever Onderzoeksoutput

  Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

• Activity-based protein profiling of glucosidases, fucosidases and glucuronidases Onderzoeksoutput

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

• in patients with vocal fold atrophy with or without sulcus; treatment modalities and outcome Agenda - 16 oktober 2024

  Promotie

• Call for Papers and Panels: Global Transformations and Governance Challenges (GTGC) Conferentie 2023 Nieuws - 24 november 2022

  Van 7-9 juni 2023 organiseert Global Transformations and Governance Challenges (GTGC) haar tweede internationale conferentie in Den Haag. Deadline voor inzendingen: 15 februari 2023.

• 
  Inge Ligtvoet Secretaris

  Faculteit der Geesteswetenschappen

• 
  Liwen Meng Promovendus / contract

  Faculteit der Sociale Wetenschappen

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  Peter van der Zwan Universitair hoofddocent

  Faculteit Rechtsgeleerdheid

• 
  Peter de Knijff Hoogleraar Populatie- en Evolutiegenetica

  Faculteit Geneeskunde

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  Nadia Garnefski Universitair hoofddocent

  Faculteit der Sociale Wetenschappen

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  Tommy van Avermaete Vakreferent

  Universitaire Bibliotheken Leiden

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  Alies Jansen Promovendus

  Faculteit der Geesteswetenschappen

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  Abdourahamane Idrissa Abdoulaye Universitair docent Islam in Sub-Sahara Afrika

  Afrika-Studiecentrum

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  Susan van den Brink Promovendus

  Wiskunde en Natuurwetenschappen

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  Antonius Johannes Rabelink Hoogleraar Interne Geneeskunde in het bijzonder de nierziekten

  Faculteit Geneeskunde

• Concerns and opportunities related to discontinuation of treatment in rheumatoid arthritis Agenda - 18 januari 2024

  Promotie

• Nanoparticle-based combination drug delivery systems for effective cancer treatment Agenda - 25 juni 2024

  Promotie

• Call for Papers and Panels: Global Transformations and Governance Challenges (GTGC) Conferentie 2022 Nieuws - 1 april 2022

  Van 8-10 juni 2022 organiseert Global Transformations and Governance Challenges (GTGC) haar eerste internationale conferentie in Den Haag. Deadline voor inzendingen: 22 april 2022.

• Tien jaar Life Science and Technology Nieuws - 1 september 2009

  Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.

• Waste Collection Systems Assessed and Good Practices Identified (COLLECTORS) Onderzoeksproject

  What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?