Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Possible improvements for the assessment of abiotic depletion in LCA.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.

We are very excited to announce our Sustainability Series for 2023-2024. Each month an interactive workshop will be organised that discusses a specific theme of sustainability. Interested about sustainability? Do not hesitate to sign up to our events !

It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.

Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Een team van Nederlandse wetenschappers heeft een supercomputer gebouwd ter grootte van vier pizzadozen. De Little Green Machine II heeft het rekenvermogen van 10.000 pc's en zal gebruikt worden door onderzoekers in de oceanografie, informatica, kunstmatige intelligentie, algoritmiek, financiële modellering…

Het ontwikkelen en delen van nieuwe methoden om signalen van toenemende angst en stress zo vroeg mogelijk te herkennen, zodat jeugdigen snel laagdrempelige, effectieve hulp kunnen ontvangen.

In deze aflevering praten we met Leonie Vreeke en Nina Komrij over het onderzoeksproject Cool Little Kids. CLK onderzoekt de effectiviteit van het trainen van ouders van angstige peuters om te voorkomen dat hun kinderen op latere leeftijd angst ontwikkelen. Wil je meer weten over hun onderzoek en ontdekken…

Vanuit de universiteit Leiden zijn wij nog opzoek naar personen en organisaties die ons kunnen helpen bij het uitvoeren van het onderzoeksproject

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

Zwangerschap veroorzaakt sterke veranderingen in hersenfuncties en die veranderingen beïnvloeden de band tussen moeder en kind. Dat ontdekten onderzoekers van Amsterdam UMC en de Universiteit Leiden. Met hun onderzoek, gepubliceerd in Nature Communications, schijnen ze licht op dit lang onontgonnen…

Een kindje dat in de baarmoeder minder voedingsstoffen krijgt dan zijn of haar eeneiige tweelingbroer of -zus, heeft op latere leeftijd vaker ontwikkelingsproblemen. Dat schrijven onderzoekers van het Leids Universitair Medisch Centrum in The Lancet Child & Adolescent Health. Deze studie laat zien dat…

How does one become a guest author for Nobel Prize winner Dr. Denis Mukwege Foundation? One of our alumni, Mariasole Forlani, can tell you all about it.

Met een historisch cortège vierde de Universiteit Leiden op 8 februari haar 444ste verjaardag. Dit jaar werd de dies natalis niet alleen gevierd met een traditiegetrouwe plechtigheid in de Pieterskerk, maar ook met activiteiten om de band aan te halen met inwoners van de universiteitssteden Leiden en…

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

Benieuwd wie er in 2019 allemaal aan de start zijn verschenen? Bekijk onderstaande lijst: