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673 zoekresultaten voor “cell chemistry” in de Publieke website

• Composition and function of integrin adhesions Onderzoeksoutput

  Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

• Analysis of sub-visible particles in complex injectable formulations Onderzoeksoutput

  Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

• High throughput microscopy of mechanism-based reporters in druginduced liver injury Onderzoeksoutput

  Promotor: B. van de Water

• Phase separation in lipid-based nanoparticles: exploring the nano-bio interface Onderzoeksoutput

  This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

• Chemical functionalization of the graphene surface for electrical and electrochemical sensing application Onderzoeksoutput

  Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

• Optimization of quantum algorithms for near-term quantum computers Onderzoeksoutput

  This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

• Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs Onderzoeksoutput

  Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

• Inhibitor Selectivity: Profiling and Prediction Onderzoeksoutput

  Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

• Single-cell immune profiling of atherosclerosis Agenda - 28 maart 2024

  Promotie

• Red cell transfusion in critically ill patients Agenda - 30 mei 2023

  Promotie

• How costimulation directs regulatory T cell responses Agenda - 29 oktober 2024

  Promotie

• The role of autophagy during carbon starvation in Aspergillus niger Onderzoeksoutput

  Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

• Investigations on the role of impaired lysosomes of macrophages in disease Onderzoeksoutput

  The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

• CO2 reduction on post-transition metals and their alloys: an industrial approach Onderzoeksoutput

  This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

• Onderzoeksfaciliteiten

• 
  Francesco Buda Universitair hoofddocent

  Wiskunde en Natuurwetenschappen

• 
  Roxanne Kieltyka Universitair hoofddocent

  Wiskunde en Natuurwetenschappen

• 
  Mario van der Stelt Hoogleraar Moleculaire fysiologie

  Wiskunde en Natuurwetenschappen

• Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics Onderzoeksproject

  Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

• A chemical biology approach for targeting of ligand-drug conjugates Onderzoeksoutput

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

• Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy Onderzoeksoutput

  In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

• Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A Onderzoeksoutput

  Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

• Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing Onderzoeksoutput

  Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

• Affinity-based profiling of the adenosine receptors Onderzoeksoutput

  The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

• A molecular journey : tales of sublimating ices from hot cores to comets Onderzoeksoutput

  The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

• NMR Faciliteit Onderzoeksfaciliteit

  Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

• From midplane to planets : the chemical fingerprint of a disk Onderzoeksoutput

  This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

• 1 PhD Candidate to study transcription factor binding to chromatin at the single-molecule level Vacature

  Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)

• Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading Agenda - 9 januari 2024

  Promotie

• Voorlichtingswebinar minor Sustainable Chemistry and Biotechnology Agenda - 2 maart 2022

  Studievoorlichting

• Click to Release for Immunce Cell Activation Agenda - 13 februari 2024

  Promotie

• Genetic-Tracing of CD8+ T cell fate decisions Agenda - 15 februari 2023

  Promotie

• Software Onderzoeksfaciliteit

  Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

• Bioorthogonal chemistry to unveil antigen processing events Agenda - 23 november 2023

  Promotie

• Atom addition reactions in interstellar ice - new pathways towards molecular complexity in space - Onderzoeksoutput

  Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

• Non-linear astrochemical kinetics: theory and applications Onderzoeksoutput

  This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

• Nanowire based Tandem Solar Cells Onderzoeksproject

  In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

• SiTaSol Onderzoeksproject

  What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

• Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles Onderzoeksproject

  What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

• Ecological functioning of bacterial chitinases in soil Onderzoeksoutput

  Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

• Dynamics of TNFalpha signaling and drug-related toxicity Onderzoeksoutput

  In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

• Precision modeling of breast cancer in the CRISPR era Onderzoeksoutput

  The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

• Coiled-coils on lipid membranes: a new perspective on membrane fusion Onderzoeksoutput

  Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

• Circulating cells as biomarkers in cardiovascular disease : the difference between men and women Onderzoeksoutput

  Promotor: J. Kuiper

• Exploitation of host chemokine signalling by pathogenic mycobacteria Onderzoeksoutput

  Promotores: A.H. Meijer, H.P. Spaink

• Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems Onderzoeksoutput

  Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

• Computational modeling of angiogenesis : from matrix invasion to lumen formation Onderzoeksoutput

  Promotor: Roeland M.H. Merks

• Photocleavable activity-based acid glucosylceramidase probes Onderzoeksoutput

  Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

• Antibiotic Discovery: From mechanistic studies to target ID Onderzoeksoutput

  The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

• Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum Onderzoeksoutput

  The applications of studying the early development of insects range from agriculture to material science.