440 zoekresultaten voor “synthesis biology” in de Publieke website
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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The tension between nature conservation and economic valuation of ecosystem services
Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Daniel Zumel Gete
Wiskunde en Natuurwetenschappen
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Anagnostis Theodoropoulos
Wiskunde en Natuurwetenschappen
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Peter van Welzen
Wiskunde en Natuurwetenschappen
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Sam Boerlijst
Wiskunde en Natuurwetenschappen
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Evidence Synthesis Methods for Continuous Outcomes
Promotie
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Development of homogeneous catalysts for the selective conversion of levulinic acid to caprolactam
Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent
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Hans de Iongh
Wiskunde en Natuurwetenschappen
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Meet Biology Leiden
Studievoorlichting
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Meet Biology Leiden
Studievoorlichting
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Next generation lipopeptide antibiotics
This thesis describes the evaluation of novel natural products with antibacterial activity enabled by total chemical synthesis.
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Jeroen Codee
Wiskunde en Natuurwetenschappen
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Iron complexes as electrocatalysts for the water oxidation reaction
In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
- Biology MSc diploma uitreiking
- MSc Biology diploma ceremonies
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Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
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Assistant Professor in Automated Reasoning (0.8-1.0 FTE)
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Contact
Neem contact op met de afdeling Environmental Biology
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Chemical Protein Synthesis: from Nanobodies to Activity-Based Probes
Promotie
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Projecten
Projecten van de afdeling Environmental Biology
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Onderwijs
Een uitgebreid overzicht van het onderwijs van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website
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Publicaties
Een uitgebreid overzicht van de publicaties van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website
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Onderzoek
Een uitgebreid overzicht van het onderzoek van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
- PhD: Modeling the mechanical regulation of plant development and regeneration (1.0 FTE)
- Postdoc Three-dimensional simulation models of plant tissue mechanobiology (1.0 FTE for three years)
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Luka Narisha
Wiskunde en Natuurwetenschappen
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Lan Dupuis
Wiskunde en Natuurwetenschappen
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Emily Strange
Wiskunde en Natuurwetenschappen
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Software en Data
Een uitgebreid overzicht van software en data beschikbaar gesteld door de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
- Ceremonie MSc Biology diploma uitreiking sessie 1
- Ceremonie MSc Biology diploma uitreiking sessie 2
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PhD student in Plant - Microbe symbiosis
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Twee NWO ECHO subsidies voor de Leidse Chemie
Twee jonge excellente chemici, Jeroen Codée en Sander van Kasteren, hebben een ECHO subsidie van € 260.000 euro toegekend gekregen door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Hiermee kunnen hun onderzoeksprojecten van start gaan.