Naar zelfregulerend leren bij spreek- en gespreksvaardigheid in moderne vreemde talen in het voortgezet onderwijs: een adaptieve en praktische aanpak.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Didactiek

De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).

Het ICLON doet onderzoek naar het basis- en voortgezet onderwijs.

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Dit onderzoek richt zich op het proces waarmee docenten eigen lespraktijk stapsgewijs kunnen aanpassen in de richting van activerende didactiek en gedifferentieerd onderwijs.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Promotor: B. van de Water

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Op 20 januari 2022 verdedigde Marco Stam het proefschrift 'Essays on Welfare Benefits, Employment, and Crime'. Het promotieonderzoek is begeleid door prof.dr. M.G. Knoef.

BRAIN Biotech en het Instituut Biologie Leiden (IBL) van Leiden Universiteit gaan samen een Aspergillus schimmelstam verder ontwikkelen. Deze zal in staat zijn meer te produceren en daarmee een biologische circulaire economie stimuleren. De samenwerking is gebaseerd op BRAINs moleculaire hulpmiddel…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: B. van de Water

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

In dit artikel analyseren Lydie Cabane en Martin Lodge analyseren de invloed van institutionele keuzes op het aanpassen van beleidsintegratie in grensoverschrijdende crisisbeheersing.

Stimuleren van Prestaties en Motivatie in de Eerste Jaren van het Voortgezet Onderwijs

Promotie

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Roeland M.H. Merks

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager