Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Onderwijsvernieuwingen komen en gaan, maar er is één onderwijsideaal dat altijd zal blijven bestaan: studenten uitdagen op hun eigen niveau om diepgaand na te denken over en met de leerstof.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Juist bij het vak Engels in het tweetalig onderwijs is er sprake van grote onderlinge niveauverschillen tussen leerlingen. Deze leerlingen moeten snel op een hoog niveau worden gebracht om de vakken te kunnen volgen die in het Engels gegeven worden. Ook zijn de eisen die worden gesteld aan het vak Engels…

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Wat is het effect van digitale leeskilometers op de leesvaardigheid van beginnende lezers in groep 3?

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotie

Werken vanuit boeiende en relevante taken

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Naar zelfregulerend leren bij spreek- en gespreksvaardigheid in moderne vreemde talen in het voortgezet onderwijs: een adaptieve en praktische aanpak.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Didactiek

De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).

Het ICLON doet onderzoek naar het basis- en voortgezet onderwijs.

Promotor: B. van de Water

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Dit onderzoek richt zich op het proces waarmee docenten eigen lespraktijk stapsgewijs kunnen aanpassen in de richting van activerende didactiek en gedifferentieerd onderwijs.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Op 20 januari 2022 verdedigde Marco Stam het proefschrift 'Essays on Welfare Benefits, Employment, and Crime'. Het promotieonderzoek is begeleid door prof.dr. M.G. Knoef.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

BRAIN Biotech en het Instituut Biologie Leiden (IBL) van Leiden Universiteit gaan samen een Aspergillus schimmelstam verder ontwikkelen. Deze zal in staat zijn meer te produceren en daarmee een biologische circulaire economie stimuleren. De samenwerking is gebaseerd op BRAINs moleculaire hulpmiddel…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: B. van de Water

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Frans in perspectief

Promotie

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.