1,553 zoekresultaten voor “specific for a” in de Publieke website
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Dreaming of You: A Writing Course on Crushes
Kunst en vrije tijd, Kunst en vrije tijd
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
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Towards a working model of industry and higher education collaboration in enhancing engineers’ soft skills for better employability
De discussie over inzetbaarheid van afgestudeerden in het hoger onderwijs bestaat al een aantal jaren. Toch staan universiteiten nog steeds voor de uitdaging om afgestudeerden te leveren die aan de verwachtingen van het bedrijfsleven kunnen voldoen.
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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‘Non-Istanbulites’ of Istanbul: Quest for a place in Istanbul in the Turkish novel since the 1960s
Dit onderzoek richt zich op een historisch-sociale analyse van een geselecteerd corpus van romans uit de moderne Turkse literatuur die het thema delen van de migratie van Anatolische steden en dorpen naar Istanbul en de strijd van immigranten in deze stad tegen verschillende uitsluitingsmechanismen.
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Ilse Markensteijn
Wiskunde en Natuurwetenschappen
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Solution for Critical Raw Materials - an European Export Network (SCRREEN)
Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Tailored care for children at high risk for problem behaviour
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PhD candidate - biodiversity & society: the Dutch home as a multispecies space
The Faculty of Science is looking for a:PhD candidate - biodiversity & society: the Dutch home as a multispecies spaceVacancy number: 14709 Project descriptionA substantial part of biodiversity is situated within private spheres of homes and this is also the biodiversity that most intimately affects…
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AI for Healthcare Robotics
Eduard Fosch-Villaronga en Hadassah Drukarch van eLaw - Centrum voor Recht en Digitale Technologie, publiceerden onlangs het boek 'AI for Healthcare Robotics', uitgegeven door CRC Press van Taylor en Francis Group in hun AI for Everything-serie.
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Erasmus+ for Teaching Assignments
PhD, Medewerker
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Erasmus+ for Training
PhD, Medewerker
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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Erasmus+ for Studies
Bachelor, Master, PhD
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Erasmus+ for Traineeships
Bachelor, Master, PhD
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Centre for Linguistics (LUCL)
Het Leiden University Centre for Linguistics (LUCL) is een van de instituten van de Faculteit Geesteswetenschappen.
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Spectropolarimetry for planetary exploration
Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik
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Centre for Digital Humanities
Het Leiden University Centre for Digital Humanities (LUCDH) is een interdisciplinair centrum dat studenten en medewerkers uit de hele Leidse gemeenschap samenbrengt.
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Uni for City themamiddagen
Uni for City, de naam verklapt het al een beetje, is een serie interactieve themamiddagen waarbij we in gesprek gaan met inwoners van Leiden en Den Haag om beter zicht te krijgen op de maatschappelijke thema’s waarin wij er als universiteit voor de stad kunnen zijn.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Fit for the future
Het boek 'Fit for the future' bundelt de bijdragen van Leidse wetenschappers en behandelt de uitdagende onderwerpen op de agenda van het Nederlandse EU-voorzitterschap 2016.
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Institute for Chemical Immunology
Overkleeft
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Centre for Professional Learning
Opleidingen voor professionals op academisch niveau om vraagstukken van vandaag en morgen rondom beleid en bestuur op te lossen. Het team van CPL bestaat uit academische professionals in public affairs, veiligheid, diversiteit en inclusie, publiek leiderschap, legal technology en communicatie.
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
- Laboratory for Ceramics Studies
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Laboratory for Astrophysics
We simuleren interstellaire wolken met speciale plasma-expansies en chemische reacties op ijzige stofdeeltjes in ultrahoogvacuümopstellingen. Dit levert gegevens die nodig zijn om astronomische waarnemingen te interpreteren en de reactienetwerken in de ruimte te modelleren.
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In shape for photoregulation
Pandit
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Error bounds for discrete tomography
Promotores: K.J. Batenburg, B. Koren
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Laboratory for Artefact Studies
Commerciële bedrijven die gebruik willen maken van de expertise en faciliteiten worden doorverwezen naar LAB , de commerciële eenheid die verantwoordelijk is voor gespecialiseerd laboratoriumwerk.