Promotor: M.A.G.J. Orrit

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

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Het Leiden Leadership Centre is een interdisciplinaire netwerkorganisatie. Als onderdeel van het Instituut Bestuurskunde van de Universiteit Leiden neemt het LLC een verbindende rol op zich door samen te werken met studenten, professionals uit de praktijk en wetenschappers vanuit verschillende disci…

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Dit zijn de mensen die binnen de Universiteit Leiden actief zijn op het gebied van kunstmatige intelligentie.

Historische migratiestudies hebben zich lange tijd voornamelijk gericht op de Europese en Atlantische wereld. In dit programmatische langetermijnproject willen we het perspectief verbreden naar de volledige migratie-ervaring van de niet-westerse wereld.

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Promotor: M.L. van Hecke

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotor: Prof.dr. J. Kuiper

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotor: Prof.dr. M.L. van Hecke

Promotor: J.W.M. Frenken

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. G.R. de Snoo

Promotor: A. Kros