247 zoekresultaten voor “plaats formation” in de Publieke website
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Ewine van Dishoeck
Wiskunde en Natuurwetenschappen
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Tracing the evolution of protoplanetary disks
Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Aske Plaat nieuwe wetenschappelijk directeur LIACS
Prof. dr. Aske Plaat (1966) wordt per 1 januari 2016 de nieuwe wetenschappelijk directeur van LIACS, het Informatica Instituut van de Universiteit Leiden. Plaat werkt sinds 1 juli 2014 als hoogleraar Data Science bij LIACS.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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On the geometry of demixing: A study of lipid phase separation on curved surfaces
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
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Patterns in natural systems
Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris
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Aske Plaat in Trouw over zelfdenkende computers
Zelfdenkende computers: hoe slim zijn ze, en vormen ze een gevaar voor de samenleving? Drie experts gaven op 9 februari hun mening hierover in Trouw. Een van de experts is hoogleraar Data science Aske Plaat. ‘Ik heb nog nooit een intelligent systeem gezien dat iets tegen de wil van de mens deed.’
- Seminar 4: The Formation of Discourse Communities in the Early Middle Ages
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Universiteit Leiden op 5e plaats duurzaamheidslijst SustainaBul
In deze duurzaamheidsranking voor het hoger onderwijs scoort Leiden goed op het gebied van duurzaamheid in onderzoek, onderwijs en bedrijfsvoering. De jury adviseert nog zichtbaarder over alle initiatieven te communiceren.
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Cities, migration and global interdependence 1350-2000
The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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When galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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The connection between mass and light in galaxy clusters
Promotor: Koen Kuijken Co-promotor: Henk Hoekstra
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The stochastic geometry of non-Gaussian fields
Promotor: V. Vitelli, Co-promotor: J. Paulose
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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Matchmaking for open innovation: perspectives on multi-sided markets
Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)
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Exploring strange new worlds with high-dispersion spectroscopy
Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Not so smooth after all: resolving dust and gas structures in protoplanetary disks
A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Radio galaxies near the epoch of reionisation
This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Studies of dust and gas in the interstellar medium of the Milky Way
Promotor: Prof.dr. A.G.G.M. Tielens
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Making the invisible visible: paramagnetic NMR and the transient protein complex
Promotor: Prof.dr. M. Ubbink
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Selectivity and competition between the anodic evolution of oxygen and chlorine
Sustainable energy from wind and solar is most readily available near the sea.
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Squaramide-based supramolecular polymers : from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
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Tales of Orion: the interplay of gas, dust, and stars in the interstellar medium
Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Modelling the interactions of advanced micro- and nanoparticles with novel entities
Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.