355 zoekresultaten voor “make” in de Publieke website
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Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
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Network flow algorithms for discrete tomography
Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele
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Understanding deep meta-learning
The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.
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RAISE Onderzoek
Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Safe anytime-valid inference: from theory to implementation in psychiatry research
Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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The Regime for International Air Carrier Liability
Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Using soil inoculations for ecological restorations
How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Collateral Transactions and Shadow Banking
Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
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Development of new chemical tools to study the cannabinoid receptor type 2
The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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Social network and radical innovation: evidence from the U.S. pharmaceutical and biotechnology industry
Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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Cosmos Malabaricus
This programme aims to make the digitized archival sources of the Kerala and Tamil Nadu Archives more accessible to Indian and international scholars and to the widest possible audience, in particular to the people of Kerala.
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Supermassive Black Holes
Lezing, Studium Generale
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Leiden Alumni in New York 2025
Alumni-activiteit, New York
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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The holographic glass bead game: from superconductivity to time machines
Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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ALL-IN meta-analysis
Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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Flows of six heavy metals
Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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The Proliferation of Dissenting Opinions in International Law
Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).
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Lights in a sea of darkness: constraining the nature and properties of dark matter using the stellar kinematics in the centres of ultra-faint
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Onderwijs
In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…
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Compressed Σ-Protocol Theory
In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.
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Positive representations of algebras of continuous functions
If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Scheduled protocol programming
With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…