In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: G.P. van Wezel

Promotor: S.M. Verduyn Lunel

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Dit boek, samengesteld door voormalig BVD-historicus Dick Engelen en historicus Constant Hijzen, geeft een overzicht van lokaties in Nederland die in de twintigste eeuw iets te maken hebben gehad met spionage en geheime diensten uit binnen- en buitenland.

Cardiovascular syndromes are the major cause of death in Western societies.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: J. Schaye

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. J. Kuiper

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: P.D. Grünwald

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Prof.dr. J. Memelink

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Sport Data Center

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Promotor: A.P. IJzerman

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…