676 zoekresultaten voor “diagnostics and treatment” in de Publieke website
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Towards personalized treatment for high risk endometrial cancer
Promotie
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Substrate Identification and Treatment of Right Ventricular Tachycardia
Promotie
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Optimizing antiseizure medication treatment in glioma patients with epilepsy
Promotie
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Quality assessment and multi modalty in gastric cancer treatment
Promotie
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Updates in Molecular Diagnosis and Targeted Treatment of Thyroid Neoplasia
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Predicting outcomes of breast cancer treatment in older patients
Promotie
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the C&D waste management systems in the Netherlands, Belgium, Spain and Finland
What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Promotie
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Exploring the mechanisms of metastatic onset for novel treatment strategies
Promotie
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Optimizing antifungal treatment through pharmacometrics: dosing considerations for enhanced efficacy
Promotie
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
Promotie
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Strategies to optimise the treatment of community-acquired pneumonia
Promotie
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
Promotie
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Quantitative Pharmacology Approaches to Inform Treatment Strategies Against Tuberculosis
Promotie
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Evidence-based treatment of central serous chorioretinopathy
Promotie
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Astrophysical plasma modeling of the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.
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Patient readiness for shared decision making about treatment
Promotie
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Potentiation of Gram-positive specific antibiotics against Gram-negative bacteria through outer membrane disruption
Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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of nanocarriers to improve the effectiveness of colorectal cancer treatment
Promotie
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Paul WoutersFaculteit der Sociale Wetenschappen
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Frank BaasFaculteit Geneeskunde
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Jian WangFaculteit der Sociale Wetenschappen
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Vincent ChangFaculteit der Geesteswetenschappen
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Ewout SteyerbergFaculteit Geneeskunde
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Oscar RuedaWiskunde en Natuurwetenschappen
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
Promotie
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Promotie
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Patient derived zebrafish xenograft models for personalized treatment of uveal melanoma
Promotie
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
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Clinical pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
Promotie
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Cattle-talk: the language of colour among East African pastoralists
What categories exist in the languages of pastoralists? Do these semantic concepts reflect universal or languagespecific tendencies? What (environment? culture?) governs the similarities (or the differences) attested crosslinguistically in cattle colour systems?
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Treatment optimisation and pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
Promotie
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Treatment with anti-CGRP (receptor) antibodies for migraine: Can we predict effectiveness?
Promotie
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Crossing borders - on the treatment of stage III melanoma and Merkel cell carcinoma
Promotie
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from unravelling the impact of smoking to exploring new views on treatment strategies
Promotie
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh