Promotor: M.K. Richardson, Co-Promotor: F. Witte

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: S.M. Verduyn Lunel

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

This thesis describes the design, characterization and application of dextran based crosslinked network.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Promotores: J. Jonkers, K.E. de Visser

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotores: G.W. Canters, T.J. Aartsma

Promotor: J. Zaanen

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Promotor: Prof.dr. M. de Jong

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Leiden University Proudly Announces Dr. Mikiko Otani as the Rotating Honorary Chair Enforcement of Children's Rights 2023/2024

Promotie

Promotie

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Disclaimer: Manuscripten die te maken hebben met het Resilience Center zijn alleen voor academische doeleinden en zijn niet bedoeld voor massaverspreiding of kopiëren. Raadpleeg de toepasselijke wetten voor eerlijk gebruik, inclusief de beperkingen van de houders van auteursrechten op publicaties.

Onder redactie van Ton Liefaard, Stephanie Rap and Peter Rodrigues is het boek ‘Monitoring Children’s Rights in the Netherlands. 30 Years of the UN Convention on the Rights of the Child’ (Leiden University Press) verschenen.

Lees meer over selectief mutisme

De masterspecialisatie Forensische Gezinspedagogiek gaat over ongunstige opvoedingsomstandigheden, zoals kindermishandeling, huiselijk geweld, vechtscheidingen en opgroeien in een kindertehuis of jeugdinrichting.

De masterspecialisatie Kinderen met Leer- en Gedragsproblemen in het onderwijs bereidt je voor om in het onderwijs aan de slag te gaan met kinderen en jongeren met probleemgedrag.

De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding. Je Leidse bachelordiploma Psychologie geeft je toegang tot de masteropleiding Psychologie in Leiden.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

Ongeveer een derde van de ouders en jonge kinderen (van 0 – 4 jaar) hebben na de eerste nationale lockdown van 2 maanden stress ervaren bij de terugkeer naar het kinderdagverblijf, zoals gerapporteerd door ouders in een grootschalig online vragenlijstonderzoek.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.