Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Onderzoekers hebben een materiaal ontwikkeld dat ingaat tegen een van de basisprincipes van de natuurkunde. Reguliere materialen die ingedrukt worden, verspreiden de druk gelijkmatig, ongeacht waar die vandaan komt. Het nieuwe materiaal breekt met deze wetmatigheid en dat kan interessant zijn voor toepassingen…

Met optimale combinaties van antibiotica kun je bacteriën beter bestrijden en tegelijk voorkomen dat ze snel resistent worden. Wetenschappers uit vijf Europese landen gaan zulke combinaties vaststellen en anderen helpen dat te doen. De Leidse hoogleraar Coen van Hasselt coördineert het project.

Het Nederlandse koloniale verleden in Indonesië heeft grote invloed gehad op de literatuur.

In een aflevering van de Tim en Paul Geschiedenis Podcast geeft Tristan Mostert uitleg over de VOC en de specerijenhandel.

In 1899 publiceerde de Indische schrijfster Dé-Lilah (pseudoniem van Lucy van Renesse) Mevrouw Klausine Klobben op Java, een fascinerend reisverhaal waarin ze enigszins gefictionaliseerd haar vijf maanden durende reis over Java beschreef.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Neurolaw is een relatief jonge discipline, waarin de impact van de neurowetenschappen op het recht, de juridische praktijk en de criminologie wordt onderzocht. De actuele ontwikkelingen binnen de neurowetenschappen (neurobiologie, -psychologie en -psychiatrie) hebben de betekenis van onderzoek op dit…

Zoutkristallen, een golfstick van nanoformaat en gesmolten glas. De LION Image Award-wedstrijd van 2023 leverde weer een heleboel prachtige beelden op. Maar uiteindelijk kan er maar één de winnaar zijn.

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.

Hoe beslist een embryonale stamcel of het een hart- of een niercel wordt? Dat is de vraag die rekenkundig biologe Maria Mircea bestudeerde voor haar promotieonderzoek. Ze keek naar de binnenkant van individuele cellen om te analyseren hoe ze veranderen. Dit is wat ze ontdekte.

Het is de groep van Daniela Kraft gelukt om een netwerk van microdeeltjes te maken dat zowel sterk als volledig flexibel is. Dat klinkt misschien simpel, maar toch zijn ze wereldwijd de eersten die hierin geslaagd zijn. Een heuse doorbraak in de natuurkunde van zachte materie.

Promovenda Jiangnan Ding onderzoekt hoe je een blok rubber zo kunt ontwerpen dat het dienst kan doen als een mechanische computerbit. Zo'n zogenaamd mechanisch metamateriaal wordt op een specifieke manier samengeperst om de vorm te veranderen. ‘Met een heel eenvoudig materiaal kunnen we in de toekomst…