Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Heart failure is a major health care problem with high mortality.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Dit artikel belicht hoe betere monetair-fiscale coördinatie zich naar verwachting zal ontwikkelen in zeer verschillende politiek-economische contexten.

Op 10 november 2016 organiseerde het Hazelhoff Centre for Financial Law een symposium over 'Ethics and Moral Hazard in the Banking Union' in het historische Academiegebouw van de Universiteit Leiden.

Het boek biedt verschillende theoretische perspectieven om het proces van publieke sector hervormingen te onderzoeken. Daarnaast geeft het een overzicht van de belangrijkste trends in publieke sector hervormingen in Europa en de Verenigde Staten.

Dit project brengt het beleid van ‘Paz Total’ (Totale Vrede) en de lopende vredesonderhandelingen tussen gewapende niet-statelijke groeperingen en de regering van Colombia onder het presidentschap van Gustavo Petro (2022-2026) in kaart.

Wat is het effect van maatschappelijke veranderingen, persoonlijke levensomstandigheden en migratiebeleid op iemands besluit te migreren?

Proefschrift van de politicoloog Luzia Helfer (Universiteit Leiden), die in Nederland en in Zwitserland onderzocht op basis van welke criteria journalisten politiek nieuws selecteren en hoe politici besluiten wel of niet te reageren op het nieuws.

Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.

In hoeverre was arbeidsmigratie belangrijk voor het functioneren van de steden in Romeins Italië?

Stimuleren van Prestaties en Motivatie in de Eerste Jaren van het Voortgezet Onderwijs

Geesteswetenschappen, Institute for Area Studies

Sinds 2009 behaalden 91 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

The combination of data science and sports is a hot topic. In a talk during the opening of the Academic Year at the Faculty of Science, Professor Joost Kok explained what data analytics can teach us about sports.

Dit recent verschenen boek analyseert en verklaart de opkomst en ondergang van Nederland als koloniale mogendheid vanuit militair perspectief.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

Wat is de institutionele dynamiek van de goedkeuring van wetgeving inzake de interne markt?

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

A new publication on changes in the relationship between news and their public in Chile

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Op 3 september 2019 verdedigde Ilektra Antonaki haar proefschrift 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. Het promotieonderzoek is begeleid door promotor prof.dr. S.C.G. Van den Bogaert.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.