Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. E.F. van Dishoeck

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Including modelling as part of software development appears to have various benefits.

In de tweede helft van de negentiende eeuw groeide Amsterdam uit tot hoofdstad van Nederland. Maar zagen de negentiende-eeuwse Amsterdammers zichzelf ook als Nederlanders? Dit boek laat zien hoe dienstmeisjes en schoenmakers, winkeliers en schooljongens hun Nederlanderschap in het dagelijkse Amsterdamse…

Make use of this time to improve your language skills by signing up for custom-made online language classes.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

Promotor: H.W. Lenstra

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: Prof.dr. G.R. de Snoo

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotor: Prof.dr.ir. E. Deprettere

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotor: J.W. van Holten

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros