Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Het scriptiearchief dat te vinden was op de website van het Mathematisch Instituut wordt momenteel overgezet naar het Leids Repositorium. Binnenkort kunnen daar de theses vanaf 2008 worden geraadpleegd.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Het Mathematisch Instituut is een van de acht instituten van de Faculteit der Wiskunde en Natuurwetenschappen. Het instituut opereert als een eenheid gedefinieerd door de activiteiten van de medewerkers.

There is no heritage without emotional sharing and clashing. This article explores the involvement of divergent emotions in heritage making by discussing the debate series of Imagine IC and the Reinwardt Academy and zooming in on the commemoration of slavery and imagery of ‘Black Pete’ in the Netherlands.…

Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.

SEAtrans: an interdisciplinary research project that aims at studying the dynamics and processes of transitions in society-nature interactions in Southeast Asian societies.

‘De prikkels in de wetenschap zijn net zo pervers als bij de banken’, vindt UMC-bestuurder en immunoloog Frank Miedema. Staan andere belangen goed wetenschappelijk onderzoek inderdaad in de weg? Op maandag 24 maart geeft prof. Miedema een openbare lezing over ‘Science in Transition’.

Kwetsbaarheid en de daarmee samenhangende sociale weerbaarheid is waar onderzoekers van het Instituut voor Culturele Antropologie en Ontwikkelingssociologie hun fascinatie vinden. Wat verbindt een Japanse visser na de tsunami bij Fukushima met een Ghanese gouddelver in een steeds meer geïndustrialiseerde…

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

Het Mathematisch Instituut verzorgt een bachelorprogramma in de Wiskunde en masterprogramma's in de Wiskunde en in de Statistiek. Het Instituut verzorgt ook vele wiskunde- en statistiekvakken voor andere studierichtingen van de universiteit en voor Leiden University College. Zo'n 65 promovendi werken…

Lezing

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Marco Cinelli van Leiden University College (LUC) en het Centrum voor Milieuwetenschappen (CML) heeft de EURO Award ontvangen voor het Beste EJOR-Paper 2024 tijdens de Europese Conferentie over Operationeel Onderzoek in Kopenhagen.

Promotie

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

In deze masterspecialisatie volg je naast de Nederlandstalige kerncursus en scriptieseminar een aantal Engelstalige vakken en keuzeseminars. In het programma is naast de politiekwetenschappelijke inhoud ook aandacht voor onderzoeksvaardigheden.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. M. Danhof

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: Prof.dr.ir. E. Deprettere

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. A.W. van der Vaart

Liza Vromen komt op de Open Dag op 15 maart 2019 uit Haarlem om haar licht op te steken bij het pre-masterprogramma Psychologie in Leiden. Eigenlijk kijkt ze alweer verder, op zoek naar een masterspecialisatie die precies bij haar interesse aansluit.

Sociale Wetenschappen, Psychologie

Promotie

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Machine Learning is becoming a more and more substantial technology for industry.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.