1,082 zoekresultaten voor “medicine op more” in de Publieke website
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Medicijnontwikkeling is zoeken naar magic bullets
Geneesmiddelen worden steeds preciezer en innovatiever, maar ook steeds duurder. Aan universiteiten de taak om met hun innovaties meer competitie en daardoor lagere prijzen te bewerkstelligen. Dat betoogt Hubertus Irth, de nieuwe hoogleraar Biomoleculaire analyse. Oratie op 4 december.
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PROGENY
How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.
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Extreem overgewicht vraagt om medicatie op maat
Artsen en apothekers moeten bij de dosering van medicijnen meer rekening houden met overgewicht. De verdeling in het lichaam en de afbraak van een geneesmiddel kunnen bij obese patiënten aanzienlijk afwijken. Dat stelt klinisch farmacoloog Catherijne Knibbe in Annual Review of Pharmacology and Toxic…
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Relatief meer patiënten naar brandwondencentra
Een steeds groter percentage slachtoffers met brandwonden gaat naar gespecialiseerde brandwondencentra. Dat blijkt uit onderzoek van Jan Dokter, brandwondenarts en medisch coördinator van het brandwondencentrum in het Maasstad Ziekenhuis te Rotterdam. Promotie op 20 december.
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‘Organen-op-een chip’ gaan de markt op
Honderden nagebootste micro-organen op een chip, met minuscule kanalen die als bloedvaten dienen. Ze kunnen de geneesmiddelenontwikkeling naar een hoger plan tillen en dierproefgebruik verminderen. Leidse onderzoekers en hun spin-off bedrijf Mimetas gaan hun ’organs-on-a-chip’ nu op de markt brengen…
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Metabolomics Faciliteit
We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…
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Elise Dusseldorp
Faculteit der Sociale Wetenschappen
- Information activities
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‘Samenwerking metabolomics in fieldlab Phenomix brengt de praktijk naar de universiteit’
Op 9 juli openende het nieuwe Medical Delta Fieldlab Phenomix haar deuren. In het fieldlab werken wetenschappers, zorginstellingen en bedrijven samen praktische toepassingen van metabolomics-onderzoek: onderzoek naar stofwisselingsproducten. Medical Delta sprak met de Leidse hoogleraar Thomas Hankemeier.…
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Postdoc - Translational Pharmacology in antibiotic regimen development
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Online Master’s Experience: Master Transfusion Medicine and Cellular and Tissue Therapies
Studievoorlichting
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.
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Nikolay Ivanovich Pirogov and his contribution to Medicine in 19th Century Imperial Russia
Promotie
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Attacks on hash functions and applications
Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Collateral Transactions and Shadow Banking
Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).
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Leids onderzoeker Andreas Bender wint prestigieuze EFMC prijs
Andreas Bender, universitair docent bij de onderzoeksgroep Medicinal Chemistry van het Leiden / Amsterdam Center for Drug Research, ontving de
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European Lead Factory
Overkleeft
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Complex Patterns in Streams
The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…
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HOPES Onderzoek
Het HOPES Onderzoek is een van de grootste onderzoeken van dit soort tot nu toe! Door bestaande hersenscans en gegevens van meer dan 4.000 jongeren tussen 14 en 25 jaar te bestuderen, hoopt het projectteam specifieke veranderingen in de hersenen te identificeren die jongeren kwetsbaar maken voor zelfmoordgedachten…
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Disentangling a complex genus: systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae
The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Real-time tomographic reconstruction
With tomography it is possible to reconstruct the interior of an object without destroying.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Publicatie: Woodcuts as Reading Guides. How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550)
In the first half of the sixteenth century, the Low Countries saw the rise of a lively market for practical and instructive books that targeted non-specialist readers. This study shows how woodcuts in vernacular books on medicine and astrology fulfilled important rhetorical functions in knowledge communication.…
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Het miljard deeltjes probleem
Promotor: Prof.dr. S. Portegies Zwart
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Enriching official economic statistics using data-driven modelling techniques
Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Many objective optimization and complex network analysis
This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.
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Trading Responsibility: navigating national burdens in a globalized world
International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.
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Staatscommissies/State committees
In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…
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Wild versus domestic prey in the diet of tigers
A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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Ethan Mark
Grensverleggend geschiedenis leren.
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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Schouwburgstraat Community Garden
In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.
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Stock-driven Scenarios on Global Material Demand
The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.