Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

In the first part of this thesis we study the geometry of folding patterns.

Promotor: W.T. de Groot

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotor: Prof.dr. M.K. Richardson

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Promotores: Wim Jiskoot; Ferry Ossendorp

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Promotor: G.P. van Wezel

Promotor: S.M. Verduyn Lunel

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Promotor: Prof.dr. K.J. Batenburg

Promotor: P.D. Grünwald

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Promotor: Prof.dr. J.N. Kok

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotores: A.H. Meijer, H.P. Spaink

Promotor: F. Arbab

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Promotor: Prof.dr. D. Bouwmeester

Promotor: Prof.dr. M.L. van Hecke

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

In Sofia Express gaat Jan Paul Hinrichs op zoek naar de literaire geheimen van de Bulgaarse hoofdstad Sofia, een stad waarin detectives, spionage en andere intriges nooit ver weg zijn.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.