445 zoekresultaten voor “lipid chair leon” in de Publieke website
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Léon Buskens mede-ontvanger NWO-beurs islam-onderzoek
Prof.dr. Léon Buskens (directeur NISIS en LUCIS) heeft samen met prof.dr. Thijl Sunier (VU) een NWO-beurs ontvangen voor hun onderzoeksvoorstel “Making Islam Work in the Netherlands. Islamic Authority and Islamic Law in the Netherlands among Ordinary Muslims: Recent Trends and Developments.” Dit onderzoek…
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Barend Mons appointed Chair of European Commission’s High Level Expert Group
Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Met grafeen door het lichaam reizen
Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Interactions from Lipid Membrane Deformations
Promotie
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Een vette oplossing voor eczeem
Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Rotating Honorary Chair in Enforcement of Children’s Rights 2024/2025
Jonathan Todres appointed as Rotating Honorary Chair in Enforcement of Children’s Rights 2024/2025
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Phase Separation in Lipid-based Nanoparticles
Promotie
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Cleveringa-boeken geschonken aan de Universiteit Leiden
Twee Cleveringa-boeken uit de juridische bibliotheek van Theo ten Kate zijn 24 november geschonken aan de Universiteit Leiden door diens kleinzoon Sebastiaan ten Kate. Het zijn proefschriften van W. Hugenholtz en J.G.L. Röder, beiden promovendi van Rudolph Pabus Cleveringa. Ten Kate: ‘Bij de universiteit…
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Photocatalytic redox reactions at the surface of liposomes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Molecular sensors for calcium ion detection via triplet-triplet annihilation upconversion
Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.
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Towards artificial photosynthesis on the lipid bilayer of liposomes
Promotie
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mRNA and Drug Delivery with Lipid-based Nanoparticles
Promotie
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Adriaan Gerbrands Lecture by Jason De León
Lezing, Adriaan Gerbrands Lecture
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LED3 & LUCID Drug Discovery Meeting
Congres/symposium
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Sylvestre BonnetWiskunde en Natuurwetenschappen
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Nieuwjaarsreceptie
Congres/symposium
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Artsen en burgers onder vuur in conflictgebieden
Het is tijd dat de internationale gemeenschap een halt toeroept aan oorlogsmisdaden - in het bijzonder tegen medisch personeel. Dat zei internationaal voorzitter Joanne Liu van Artsen zonder Grenzen tijdens de Cleveringa-oratie.
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Cleveringa-hoogleraar Liu weet hoe je ebola de baas wordt
Op donderdag 24 november gaf Joanne Liu een extra lezing over ebola in het Leids Universitair Medisch Centrum (LUMC). Dat deed zij voorafgaand aan haar Cleveringa-oratie op 25 november.
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Global Challenges
In the spring of 2025, Studium Generale will host several Global Challenges lectures at Leiden University College The Hague. We begin on December 10, 2024, International Human Rights Day, with a panel discussion about children's rights in conflict zones, focusing on the right to education during and…
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Anjali PanditWiskunde en Natuurwetenschappen
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The Right to Travel by Air of Persons with Disabilities
Op donderdag 16 november 2017 heeft Lalin Kovudhikulrungsri haar proefschrift ‘The Right to Travel by Air of Persons with Disabilities’ verdedigd. Haar promotoren zijn Prof.dr. P.M.J. Mendes De Leon en Prof.mr.dr. A.C. Hendriks.
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Biomarker discovery in diabetes mellitus and lipid metabolism: Multi-platform glyco(proteo)mic approaches
Promotie
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
Promotie
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Promotie
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Regulation of the immune response by unsaturated lipid mediators in the context of the osteoarthritic joint
Promotie
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Promotie
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A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions
Op donderdag 16 november 2017 is Thomas Leclerc gepromoveerd op zijn proefschrift ‘A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions. Contribution to the Study of Interactions between Legal Orders of International Law’. Zijn promotoren zijn prof.dr. P.M.J. Mendes De Leon en prof. L.…
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Legal Implications of Airport Privatization in India
Op donderdag 24 november 2016 promoveert Moses George op zijn proefschrift 'Legal Implications of Airport Privatization in India'. De verdediging vindt plaats om 11.15 uur in het Academiegebouw van Universiteit Leiden. De promotores zijn professor Pablo Mendes De Leon en professor Brian F. Havel (DePaul…
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri